Hydroxyalkylation of α-C-H bonds of tetrahydrofuran with aldehydes in the presence of triethylborane and tert-butyl hydroperoxide

Takehiko Yoshimitsu, Yoshimasa Arano, Hiroto Nagaoka

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The α-hydroxyalkylation of tetrahydrofuran with aldehydes via radical C-H abstraction was conducted using triethylborane in the presence of tert-butyl hydroperoxide. This study presents a rare instance of direct intermolecular radical addition of unactivated cyclic ether to aldehydes.

Original languageEnglish
Pages (from-to)625-627
Number of pages3
JournalJournal of Organic Chemistry
Volume68
Issue number2
DOIs
Publication statusPublished - Jan 24 2003
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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