Hydroxyalkylation of α-C-H bonds of tetrahydrofuran with aldehydes in the presence of triethylborane and tert-butyl hydroperoxide

Takehiko Yoshimitsu, Yoshimasa Arano, Hiroto Nagaoka

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The α-hydroxyalkylation of tetrahydrofuran with aldehydes via radical C-H abstraction was conducted using triethylborane in the presence of tert-butyl hydroperoxide. This study presents a rare instance of direct intermolecular radical addition of unactivated cyclic ether to aldehydes.

Original languageEnglish
Pages (from-to)625-627
Number of pages3
JournalJournal of Organic Chemistry
Issue number2
Publication statusPublished - Jan 24 2003


ASJC Scopus subject areas

  • Organic Chemistry

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