Hydroxy-carbonate apatite: Synthesis, blood compatibility and adsorption of specific pathogenic proteins

Satoshi Hayakawa, Yuko Kusudo, Shinji Takemoto, Kanji Tsuru, Akiyoshi Osaka, Seisuke Takashima

Research output: Contribution to conferencePaper

Abstract

Hydroxy-carbonate apatite (CAp) compositions containing carbonate ions from 0 to 10.9 wt% were synthesized by a wet chemical method. Infrared analysis revealed that carbonate ions were substituted both PO43- and OH- sites. The introduction of CO32- ion into the hydroxyapatite lattice led to an increase in specific surface area and surface charge density. Blood clotting properties were not affected by the contact with CAp samples. The adsorption behavior of proteins was investigated by contacting CAp with model saline containing bovine serum albumin (BSA) and β2-microglobulin (β2-MG). The selectivity against β2-MG increased with increase in the amount of carbonate ions. As surface charge density increased with increase in the amount of carbonate ions, surface charge density played an important role in selective adsorption of β2-MG, but not a sole factor.

Original languageEnglish
Pages111-119
Number of pages9
Publication statusPublished - Dec 1 2003
EventBioceramics: Materials and Applications IV, Proceedings - Nashville, TN, United States
Duration: Apr 27 2003Apr 30 2003

Conference

ConferenceBioceramics: Materials and Applications IV, Proceedings
CountryUnited States
CityNashville, TN
Period4/27/034/30/03

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ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Hayakawa, S., Kusudo, Y., Takemoto, S., Tsuru, K., Osaka, A., & Takashima, S. (2003). Hydroxy-carbonate apatite: Synthesis, blood compatibility and adsorption of specific pathogenic proteins. 111-119. Paper presented at Bioceramics: Materials and Applications IV, Proceedings, Nashville, TN, United States.