Hydrophobic effects on multivalent-salt-induced self-condensation of DNA

Tomonari Sumi, Chiaki Suzuki, Hideo Sekino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hydrophobic effects on multivalent-salt-induced self-condensation of a single polyelectrolyte chain such as DNA are investigated through a multiscale coarse-grained simulation based on density functional theory. We show that the water-mediated hydrophobic effect that was enhanced by hydration of multivalent salts plays an essential role in self-condensation of DNA. The self-condensation is interpreted as an entropy-driven compaction due to the hydration entropy gain.

Original languageEnglish
Article number161103
JournalThe Journal of Chemical Physics
Volume131
Issue number16
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Entropy
Condensation
deoxyribonucleic acid
condensation
Salts
salts
Hydration
hydration
DNA
entropy
Polyelectrolytes
Density functional theory
Water
Compaction
density functional theory
water
simulation

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry
  • Medicine(all)

Cite this

Hydrophobic effects on multivalent-salt-induced self-condensation of DNA. / Sumi, Tomonari; Suzuki, Chiaki; Sekino, Hideo.

In: The Journal of Chemical Physics, Vol. 131, No. 16, 161103, 2009.

Research output: Contribution to journalArticle

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