Hydrophobic effects on multivalent-salt-induced self-condensation of DNA

Tomonari Sumi; Chiaki Suzuki; Hideo Sekino

doi:10.1063/1.3256982

Hydrophobic effects on multivalent-salt-induced self-condensation of DNA

Tomonari Sumi, Chiaki Suzuki, Hideo Sekino

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Hydrophobic effects on multivalent-salt-induced self-condensation of a single polyelectrolyte chain such as DNA are investigated through a multiscale coarse-grained simulation based on density functional theory. We show that the water-mediated hydrophobic effect that was enhanced by hydration of multivalent salts plays an essential role in self-condensation of DNA. The self-condensation is interpreted as an entropy-driven compaction due to the hydration entropy gain.

Original language	English
Article number	161103
Journal	Journal of Chemical Physics
Volume	131
Issue number	16
DOIs	https://doi.org/10.1063/1.3256982
Publication status	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy(all)
Physical and Theoretical Chemistry

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abstract = "Hydrophobic effects on multivalent-salt-induced self-condensation of a single polyelectrolyte chain such as DNA are investigated through a multiscale coarse-grained simulation based on density functional theory. We show that the water-mediated hydrophobic effect that was enhanced by hydration of multivalent salts plays an essential role in self-condensation of DNA. The self-condensation is interpreted as an entropy-driven compaction due to the hydration entropy gain.",

author = "Tomonari Sumi and Chiaki Suzuki and Hideo Sekino",

note = "Funding Information: One of the authors (T.S.) has been inspired by a suggestion from Dr. R. Akiyama in Kyushu University that the self-condensation of DNA is an entropy-driven phenomenon. This work was supported by KAKENHI (Grant-in-Aid for Scientific Research) on Priority Area “Soft Matter Physics” from the Ministry of Education, Culture, Sports, Science and Technology, Japan. ",

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