Abstract
Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.
Original language | English |
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Pages (from-to) | 651-654 |
Number of pages | 4 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 55 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2007 |
Keywords
- Hydrolyzed thalidomide
- Metabolite
- Thalidomide
- Tumor necrosis factor (TNF)-α modulator
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery