Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Takanori Nakamura, Tomomi Noguchi, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number4
DOIs
Publication statusPublished - Apr 2007
Externally publishedYes

Fingerprint

Thalidomide
Metabolites
Tumor Necrosis Factor-alpha
Leukemia
Cells
Cell Line
glutarimide

Keywords

  • Hydrolyzed thalidomide
  • Metabolite
  • Thalidomide
  • Tumor necrosis factor (TNF)-α modulator

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Hydrolyzed metabolites of thalidomide : Synthesis and TNF-α production-inhibitory activity. / Nakamura, Takanori; Noguchi, Tomomi; Miyachi, Hiroyuki; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 55, No. 4, 04.2007, p. 651-654.

Research output: Contribution to journalArticle

Nakamura, Takanori ; Noguchi, Tomomi ; Miyachi, Hiroyuki ; Hashimoto, Yuichi. / Hydrolyzed metabolites of thalidomide : Synthesis and TNF-α production-inhibitory activity. In: Chemical and Pharmaceutical Bulletin. 2007 ; Vol. 55, No. 4. pp. 651-654.
@article{fce0eb0f013f491392a5b6d590c08f64,
title = "Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity",
abstract = "Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.",
keywords = "Hydrolyzed thalidomide, Metabolite, Thalidomide, Tumor necrosis factor (TNF)-α modulator",
author = "Takanori Nakamura and Tomomi Noguchi and Hiroyuki Miyachi and Yuichi Hashimoto",
year = "2007",
month = "4",
doi = "10.1248/cpb.55.651",
language = "English",
volume = "55",
pages = "651--654",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "4",

}

TY - JOUR

T1 - Hydrolyzed metabolites of thalidomide

T2 - Synthesis and TNF-α production-inhibitory activity

AU - Nakamura, Takanori

AU - Noguchi, Tomomi

AU - Miyachi, Hiroyuki

AU - Hashimoto, Yuichi

PY - 2007/4

Y1 - 2007/4

N2 - Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

AB - Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

KW - Hydrolyzed thalidomide

KW - Metabolite

KW - Thalidomide

KW - Tumor necrosis factor (TNF)-α modulator

UR - http://www.scopus.com/inward/record.url?scp=34147106377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34147106377&partnerID=8YFLogxK

U2 - 10.1248/cpb.55.651

DO - 10.1248/cpb.55.651

M3 - Article

C2 - 17409565

AN - SCOPUS:34147106377

VL - 55

SP - 651

EP - 654

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 4

ER -