Abstract
Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.
| Original language | English |
|---|---|
| Pages (from-to) | 651-654 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 55 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2007 |
| Externally published | Yes |
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Keywords
- Hydrolyzed thalidomide
- Metabolite
- Thalidomide
- Tumor necrosis factor (TNF)-α modulator
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Pharmacology
Cite this
Hydrolyzed metabolites of thalidomide : Synthesis and TNF-α production-inhibitory activity. / Nakamura, Takanori; Noguchi, Tomomi; Miyachi, Hiroyuki; Hashimoto, Yuichi.
In: Chemical and Pharmaceutical Bulletin, Vol. 55, No. 4, 04.2007, p. 651-654.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hydrolyzed metabolites of thalidomide
T2 - Synthesis and TNF-α production-inhibitory activity
AU - Nakamura, Takanori
AU - Noguchi, Tomomi
AU - Miyachi, Hiroyuki
AU - Hashimoto, Yuichi
PY - 2007/4
Y1 - 2007/4
N2 - Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.
AB - Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.
KW - Hydrolyzed thalidomide
KW - Metabolite
KW - Thalidomide
KW - Tumor necrosis factor (TNF)-α modulator
UR - http://www.scopus.com/inward/record.url?scp=34147106377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147106377&partnerID=8YFLogxK
U2 - 10.1248/cpb.55.651
DO - 10.1248/cpb.55.651
M3 - Article
C2 - 17409565
AN - SCOPUS:34147106377
VL - 55
SP - 651
EP - 654
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 4
ER -