Abstract
Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.
| Original language | English |
|---|---|
| Pages (from-to) | 651-654 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 55 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2007 |
Keywords
- Hydrolyzed thalidomide
- Metabolite
- Thalidomide
- Tumor necrosis factor (TNF)-α modulator
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Cite this
Nakamura, T., Noguchi, T., Miyachi, H., & Hashimoto, Y. (2007). Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity. Chemical and Pharmaceutical Bulletin, 55(4), 651-654. https://doi.org/10.1248/cpb.55.651