Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.
- Hydrolyzed thalidomide
- Tumor necrosis factor (TNF)-α modulator
ASJC Scopus subject areas
- Drug Discovery