Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Takanori Nakamura; Tomomi Noguchi; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.55.651

Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Takanori Nakamura, Tomomi Noguchi, Hiroyuki Miyachi, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

Original language	English
Pages (from-to)	651-654
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	55
Issue number	4
DOIs	https://doi.org/10.1248/cpb.55.651
Publication status	Published - Apr 2007

Keywords

Hydrolyzed thalidomide
Metabolite
Thalidomide
Tumor necrosis factor (TNF)-α modulator

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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AU - Nakamura, Takanori

AU - Noguchi, Tomomi

AU - Miyachi, Hiroyuki

AU - Hashimoto, Yuichi

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KW - Metabolite

KW - Thalidomide

KW - Tumor necrosis factor (TNF)-α modulator

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Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Abstract

Keywords

ASJC Scopus subject areas

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