Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Takanori Nakamura, Tomomi Noguchi, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number4
DOIs
Publication statusPublished - Apr 1 2007

Keywords

  • Hydrolyzed thalidomide
  • Metabolite
  • Thalidomide
  • Tumor necrosis factor (TNF)-α modulator

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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