Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration

Kentaro Noda, Yugo Tanaka, Norihisa Shigemura, Tomohiro Kawamura, Yinna Wang, Kosuke Masutani, Xuejun Sun, Yoshiya Toyoda, Christian A. Bermudez, Atsunori Nakao

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Recent evidence suggests that molecular hydrogen has therapeutic value for disease states that involve inflammation. We hypothesized that drinking hydrogen-rich water (HW) daily would protect cardiac and aortic allograft recipients from inflammation-associated deterioration. Heterotopic heart transplantation with short-course tacrolimus immunosuppression and orthotopic aortic transplantation were performed in allogeneic rat strains. HW was generated either by bubbling hydrogen gas through tap water (Bu-HW) or via chemical reaction using a magnesium stick [Mg + 2H2O â Mg (OH)2 + H2] immersed in tap water (Mg-HW). Recipients were given either regular water (RW), Mg-HW, Bu-HW, or Mg-HW that had been subsequently degassed (DW). Graft survival was assessed by daily palpation for a heartbeat. Drinking Mg-HW or Bu-HW was remarkably effective in prolonging heart graft survival and reducing intimal hyperplasia in transplanted aortas as compared with grafts treated with RW or DW. Furthermore, T cell proliferation was significantly inhibited in the presence of hydrogen in vitro, accompanied by less production of interleukin-2 and interferon-Î. Hydrogen treatment was also associated with increased graft ATP levels and increased activity of the enzymes in mitochondrial respiratory chain. Drinking HW prolongs survival of cardiac allografts and reduces intimal hyperplasia of aortic allografts.

Original languageEnglish
Pages (from-to)1213-1222
Number of pages10
JournalTransplant International
Volume25
Issue number12
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Fingerprint

Drinking Water
Allografts
Hydrogen
Inflammation
Water
Tunica Intima
Drinking
Graft Survival
Hyperplasia
Heterotopic Transplantation
Transplants
Palpation
Tacrolimus
Heart Transplantation
Electron Transport
Immunosuppression
Magnesium
Interferons
Interleukin-2
Aorta

Keywords

  • allograft vasculopathy
  • heart transplantation
  • hydrogen
  • inflammation
  • intimal hyperplasia

ASJC Scopus subject areas

  • Transplantation

Cite this

Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. / Noda, Kentaro; Tanaka, Yugo; Shigemura, Norihisa; Kawamura, Tomohiro; Wang, Yinna; Masutani, Kosuke; Sun, Xuejun; Toyoda, Yoshiya; Bermudez, Christian A.; Nakao, Atsunori.

In: Transplant International, Vol. 25, No. 12, 12.2012, p. 1213-1222.

Research output: Contribution to journalArticle

Noda, K, Tanaka, Y, Shigemura, N, Kawamura, T, Wang, Y, Masutani, K, Sun, X, Toyoda, Y, Bermudez, CA & Nakao, A 2012, 'Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration', Transplant International, vol. 25, no. 12, pp. 1213-1222. https://doi.org/10.1111/j.1432-2277.2012.01542.x
Noda, Kentaro ; Tanaka, Yugo ; Shigemura, Norihisa ; Kawamura, Tomohiro ; Wang, Yinna ; Masutani, Kosuke ; Sun, Xuejun ; Toyoda, Yoshiya ; Bermudez, Christian A. ; Nakao, Atsunori. / Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. In: Transplant International. 2012 ; Vol. 25, No. 12. pp. 1213-1222.
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