Hydrocortisone sodium succinate suppressed production of interleukin-10 by human peripheral blood mononuclear cells: Clinical significance

Hideo Kohka, Hiromi Iwagaki, Tadashi Yoshino, Kenta Kobashi, Shinnya Saito, Hiroshi Isozaki, Norihisa Takakura, Noriaki Tanaka

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis inhibitory factor. We examined the effect of hydrocortisone sodium succinate (HSS) on the production of IL-10 by human peripheral blood mononuclear cells (PBMCs). PBMCs from healthy volunteers and cancer-burden patients were preincubated separately with or without HSS for 1 h, then stimulated with 5 μg/ml lipopolysaccharide (LPS). Production of IL-10 by human PBMCs was detected with LPS stimulation and its production was higher in cancer-burden patients than in normal volunteers, although this was not statistically significant. HSS suppressed production of IL-10 by LPS-stimulated PBMCs in a dose-dependent manner both in normal volunteers and in cancer-burden patients. These results indicate that, in addition to their antiinflammatory properties, corticoids act to restore the immunosuppressive states even in cancer-burden states.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalActa medica Okayama
Volume53
Issue number1
Publication statusPublished - Dec 1 1999

Keywords

  • Cancer-burden state
  • Interleukin-10
  • Steroid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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