Hydroamination of alkynes catalyzed by palladium/benzoic acid

Leopold Mpaka Lutete, Isao Kadota, Akinori Shibuya, Yoshinori Yamamoto

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The reaction of internal alkynes (1) with amines (2) in the presence of catalytic amount of Pd(PPh3)4 and benzoic acid in dioxane at 100°C gave the allylic amines (3) in good to excellent yields. The intramolecular reaction of alkynes with tethered amino groups (4) gave 2-vinylpyrrolidines and 2-vinylpiperidines (5) in good to excellent yields.

Original languageEnglish
Pages (from-to)347-357
Number of pages11
JournalHeterocycles
Volume58
Publication statusPublished - Nov 22 2002
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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