Hydroamination of alkynes catalyzed by palladium/benzoic acid

Leopold Mpaka Lutete, Isao Kadota, Akinori Shibuya, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

The reaction of internal alkynes (1) with amines (2) in the presence of catalytic amount of Pd(PPh3)4 and benzoic acid in dioxane at 100°C gave the allylic amines (3) in good to excellent yields. The intramolecular reaction of alkynes with tethered amino groups (4) gave 2-vinylpyrrolidines and 2-vinylpiperidines (5) in good to excellent yields.

Original languageEnglish
Pages (from-to)347-357
Number of pages11
JournalHeterocycles
Volume58
Publication statusPublished - Nov 22 2002
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Hydroamination of alkynes catalyzed by palladium/benzoic acid'. Together they form a unique fingerprint.

Cite this