TY - JOUR
T1 - Human papillomavirus as a risk factor for head and neck cancers - A case-control study
AU - Nishioka, Shinji
AU - Fukushima, Kunihiro
AU - Nishizaki, Kazunori
AU - Gunduz, Mehmet
AU - Tominaga, Susumu
AU - Fukazawa, Motoharu
AU - Monden, Nobuya
AU - Watanabe, Shuichi
AU - Masuda, Yu
AU - Ogura, Hajime
PY - 1999
Y1 - 1999
N2 - A retrospective, case-control study was conducted to examine the relationship between the presence of human papillomavirus types 16 and 18 (HPV16/18) DNA and the risk of head and neck cancers. Twelve out of 74 (16.2%) head and neck cancers contained HPV16/18 DNA, while 3 out of 70 (4.2%) non-cancer controls showed HPV16/18 positivity by polymerase chain reaction. The presence of HPV16/18 DNA was associated with an increased risk of head and neck cancer formation, showing an odds ratio of 4.32, with a 95% confidence interval of 1.26-14.78. Although its epidemiological impact might be smaller than that of other factors like cigarette smoking, the presence of HPV16/18 DNA in the aerodigestive tract is suggested to be a risk factor for human head and neck cancers.
AB - A retrospective, case-control study was conducted to examine the relationship between the presence of human papillomavirus types 16 and 18 (HPV16/18) DNA and the risk of head and neck cancers. Twelve out of 74 (16.2%) head and neck cancers contained HPV16/18 DNA, while 3 out of 70 (4.2%) non-cancer controls showed HPV16/18 positivity by polymerase chain reaction. The presence of HPV16/18 DNA was associated with an increased risk of head and neck cancer formation, showing an odds ratio of 4.32, with a 95% confidence interval of 1.26-14.78. Although its epidemiological impact might be smaller than that of other factors like cigarette smoking, the presence of HPV16/18 DNA in the aerodigestive tract is suggested to be a risk factor for human head and neck cancers.
KW - Head and neck carcinomas
KW - Human papillomavirus
KW - Polymerase chain reaction
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M3 - Article
C2 - 10445085
AN - SCOPUS:0032588134
SP - 77
EP - 80
JO - Acta Oto-Laryngologica, Supplement
JF - Acta Oto-Laryngologica, Supplement
SN - 0365-5237
IS - 540
ER -