Human papillomavirus as a risk factor for head and neck cancers - A case-control study

Shinji Nishioka; Kunihiro Fukushima; Kazunori Nishizaki; Mehmet Gunduz; Susumu Tominaga; Motoharu Fukazawa; Nobuya Monden; Shuichi Watanabe; Yu Masuda; Hajime Ogura

Human papillomavirus as a risk factor for head and neck cancers - A case-control study

Shinji Nishioka, Kunihiro Fukushima, Kazunori Nishizaki, Mehmet Gunduz, Susumu Tominaga, Motoharu Fukazawa, Nobuya Monden, Shuichi Watanabe, Yu Masuda, Hajime Ogura

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A retrospective, case-control study was conducted to examine the relationship between the presence of human papillomavirus types 16 and 18 (HPV16/18) DNA and the risk of head and neck cancers. Twelve out of 74 (16.2%) head and neck cancers contained HPV16/18 DNA, while 3 out of 70 (4.2%) non-cancer controls showed HPV16/18 positivity by polymerase chain reaction. The presence of HPV16/18 DNA was associated with an increased risk of head and neck cancer formation, showing an odds ratio of 4.32, with a 95% confidence interval of 1.26-14.78. Although its epidemiological impact might be smaller than that of other factors like cigarette smoking, the presence of HPV16/18 DNA in the aerodigestive tract is suggested to be a risk factor for human head and neck cancers.

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Acta Oto-Laryngologica, Supplement
Issue number	540
Publication status	Published - 1999

Keywords

Head and neck carcinomas
Human papillomavirus
Polymerase chain reaction

ASJC Scopus subject areas

Otorhinolaryngology

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Human papillomavirus as a risk factor for head and neck cancers - A case-control study. / Nishioka, Shinji; Fukushima, Kunihiro; Nishizaki, Kazunori; Gunduz, Mehmet; Tominaga, Susumu; Fukazawa, Motoharu; Monden, Nobuya; Watanabe, Shuichi; Masuda, Yu; Ogura, Hajime.

In: Acta Oto-Laryngologica, Supplement, No. 540, 1999, p. 77-80.

Research output: Contribution to journal › Article › peer-review

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