Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer

Yukiko Yasuda, Akiko Sakai, Sachio Ito, Kaori Sasai, Akisada Ishizaki, Yoshiya Okano, Seito Kawahara, Yoshimi Jitsumori, Hiromasa Yamamoto, Nagahide Matsubara, Kenji Shimizu, Hiroshi Katayama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the refor-mation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide poly-morphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhib-ited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.

Original languageEnglish
Article number45
Pages (from-to)1-11
Number of pages11
JournalBiomedical Reports
Volume13
Issue number5
DOIs
Publication statusPublished - 2020

Keywords

  • Centrosome
  • Colon cancer
  • NINEIN
  • Single nucleotide polymorphism
  • Tumor susceptibility

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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