Human Liver Microsomal Oxidation of Δ8-Tetrahydrocannabinol

Ikuo Yamamoto, Shizuo Narimatsu, Kazuhito Watanabe, Tatsuyuki Shimonishi, Hidetoshi Yoshimura, Taizo Nagano

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Human liver microsomal oxidation products of Δ8-tetrahydrocannabi-nol (THC) were isolated and identified by thin-layer chromatography, gas chromatography and gas chromatography-mass spectrometry. As the results, five monohydroxylated metabolites including 11-hydroxy-Δ8-THC, and 8β,9α-dihydroxyhexahydrocannabinol were identified as trimethyl-silyl derivatives. Isolation of the dihydroxylated metabolite suggests that epoxy metabolite(s) may be formed from A8-THC in humans.

Original languageEnglish
Pages (from-to)1784-1787
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume31
Issue number5
DOIs
Publication statusPublished - Jan 1 1983

Keywords

  • 11-hydroxy-Δ8-tetrahydrocannabi-nol
  • 11-hydroxy-Δ8-tetrahydrocannabinol
  • 3'-hydroxy-Δ8-tetra-hydrocannabinol
  • 7α-hydroxy-Δ8-tetrahydrocannabinol
  • 7β-hydroxy-Δ8-tetrahydro-cannabinol
  • 8β,9α-dihydroxyhexahydrocannabinol
  • GC-MS
  • human liver microsomes
  • identification of metabolite
  • Δ8-tetrahydrocannabinol

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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