Human leukocyte antigen DR status and clinical features in Japanese patients with type 1 autoimmune hepatitis

Yasuhiro Miyake, Yoshiaki Iwasaki, Akinobu Takaki, Toru Onishi, Ryoichi Okamoto, Kouichi Takaguchi, Hiroshi Ikeda, Yasuhiro Makino, Haruhiko Kobashi, Kohsaku Sakaguchi, Yasushi Shiratori

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9 Citations (Scopus)

Abstract

Aim: Human leukocyte antigen (HLA) DR status affects the clinical features of autoimmune hepatitis. In Caucasians, patients with DR3 have poorer outcomes. In Japan, the relationship between HLA DR status and clinical features has yet to be fully examined. Methods: We investigated 79 patients with type 1 autoimmune hepatitis who underwent liver biopsy and were screened for HLA DR status by the polymerase chain reaction sequence specific oligonucleotide hybridization method. Results: Fifty-five patients had DR4 and 23 had DR2. Thirteen patients had both DR2 and DR4. None had DR3. Of patients aged

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalHepatology Research
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Keywords

  • Concurrent autoimmune disease
  • Human leukocyte antigen
  • Immunoglobulin G
  • Type1 autoimmune hepatitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Miyake, Y., Iwasaki, Y., Takaki, A., Onishi, T., Okamoto, R., Takaguchi, K., Ikeda, H., Makino, Y., Kobashi, H., Sakaguchi, K., & Shiratori, Y. (2008). Human leukocyte antigen DR status and clinical features in Japanese patients with type 1 autoimmune hepatitis. Hepatology Research, 38(1), 96-102. https://doi.org/10.1111/j.1872-034X.2007.00204.x