Human hepatocyte carcinogenesis (review)

Hidenori Shiraha, Kazuhide Yamamoto, Masayoshi Namba

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Hepatocellular carcinoma is the third most frequent cause of cancer-related death worldwide; and its incidence rate is increasing. Clinical and molecular medical analyses have revealed substantial information on hepatocarcinogenesis. Hepatocarcinogenesis is a stepwise process during which multiple genes are altered. Genetic changes and their biological consequences in human HCC can be divided into at least 4 groups: i) tumor suppressor genes (p53, retinoblastoma, phosphatase tensin homolog and runt-related transcription factor 3), ii) oncogenes (myc, K-ras, BRAF), iii) reactivation of developmental pathways (Wnt, hedgehog), and iv) growth factors and their receptors (transforming growth factor-α, insulin-like growth factor-2 receptor). An experimental model of human hepatocarcinogenesis such as in vitro neoplastic transformation of human hepatocytes has not been successfully achieved yet, but several immortalized human hepatocyte cell lines have been established. These immortalized human hepatocytes will become useful tools for the elucidation of hepatocarcinogenesis, especially for the initial step of multistep hepatocarcinogenesis.

Original languageEnglish
Pages (from-to)1133-1138
Number of pages6
JournalInternational Journal of Oncology
Volume42
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Hepatocytes
Carcinogenesis
Transcription Factor 3
Somatomedin Receptors
Wnt Signaling Pathway
ras Genes
Growth Factor Receptors
Retinoblastoma
Transforming Growth Factors
Tumor Suppressor Genes
Phosphoric Monoester Hydrolases
Hepatocellular Carcinoma
Theoretical Models
Cell Line
Incidence
Genes
Neoplasms

Keywords

  • Gene alteration
  • Hepatocarcinogenesis
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Human hepatocyte carcinogenesis (review). / Shiraha, Hidenori; Yamamoto, Kazuhide; Namba, Masayoshi.

In: International Journal of Oncology, Vol. 42, No. 4, 04.2013, p. 1133-1138.

Research output: Contribution to journalArticle

Shiraha, Hidenori ; Yamamoto, Kazuhide ; Namba, Masayoshi. / Human hepatocyte carcinogenesis (review). In: International Journal of Oncology. 2013 ; Vol. 42, No. 4. pp. 1133-1138.
@article{45fdfb48b5394925bac82147e2cd35fc,
title = "Human hepatocyte carcinogenesis (review)",
abstract = "Hepatocellular carcinoma is the third most frequent cause of cancer-related death worldwide; and its incidence rate is increasing. Clinical and molecular medical analyses have revealed substantial information on hepatocarcinogenesis. Hepatocarcinogenesis is a stepwise process during which multiple genes are altered. Genetic changes and their biological consequences in human HCC can be divided into at least 4 groups: i) tumor suppressor genes (p53, retinoblastoma, phosphatase tensin homolog and runt-related transcription factor 3), ii) oncogenes (myc, K-ras, BRAF), iii) reactivation of developmental pathways (Wnt, hedgehog), and iv) growth factors and their receptors (transforming growth factor-α, insulin-like growth factor-2 receptor). An experimental model of human hepatocarcinogenesis such as in vitro neoplastic transformation of human hepatocytes has not been successfully achieved yet, but several immortalized human hepatocyte cell lines have been established. These immortalized human hepatocytes will become useful tools for the elucidation of hepatocarcinogenesis, especially for the initial step of multistep hepatocarcinogenesis.",
keywords = "Gene alteration, Hepatocarcinogenesis, Tumor suppressor genes",
author = "Hidenori Shiraha and Kazuhide Yamamoto and Masayoshi Namba",
year = "2013",
month = "4",
doi = "10.3892/ijo.2013.1829",
language = "English",
volume = "42",
pages = "1133--1138",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "4",

}

TY - JOUR

T1 - Human hepatocyte carcinogenesis (review)

AU - Shiraha, Hidenori

AU - Yamamoto, Kazuhide

AU - Namba, Masayoshi

PY - 2013/4

Y1 - 2013/4

N2 - Hepatocellular carcinoma is the third most frequent cause of cancer-related death worldwide; and its incidence rate is increasing. Clinical and molecular medical analyses have revealed substantial information on hepatocarcinogenesis. Hepatocarcinogenesis is a stepwise process during which multiple genes are altered. Genetic changes and their biological consequences in human HCC can be divided into at least 4 groups: i) tumor suppressor genes (p53, retinoblastoma, phosphatase tensin homolog and runt-related transcription factor 3), ii) oncogenes (myc, K-ras, BRAF), iii) reactivation of developmental pathways (Wnt, hedgehog), and iv) growth factors and their receptors (transforming growth factor-α, insulin-like growth factor-2 receptor). An experimental model of human hepatocarcinogenesis such as in vitro neoplastic transformation of human hepatocytes has not been successfully achieved yet, but several immortalized human hepatocyte cell lines have been established. These immortalized human hepatocytes will become useful tools for the elucidation of hepatocarcinogenesis, especially for the initial step of multistep hepatocarcinogenesis.

AB - Hepatocellular carcinoma is the third most frequent cause of cancer-related death worldwide; and its incidence rate is increasing. Clinical and molecular medical analyses have revealed substantial information on hepatocarcinogenesis. Hepatocarcinogenesis is a stepwise process during which multiple genes are altered. Genetic changes and their biological consequences in human HCC can be divided into at least 4 groups: i) tumor suppressor genes (p53, retinoblastoma, phosphatase tensin homolog and runt-related transcription factor 3), ii) oncogenes (myc, K-ras, BRAF), iii) reactivation of developmental pathways (Wnt, hedgehog), and iv) growth factors and their receptors (transforming growth factor-α, insulin-like growth factor-2 receptor). An experimental model of human hepatocarcinogenesis such as in vitro neoplastic transformation of human hepatocytes has not been successfully achieved yet, but several immortalized human hepatocyte cell lines have been established. These immortalized human hepatocytes will become useful tools for the elucidation of hepatocarcinogenesis, especially for the initial step of multistep hepatocarcinogenesis.

KW - Gene alteration

KW - Hepatocarcinogenesis

KW - Tumor suppressor genes

UR - http://www.scopus.com/inward/record.url?scp=84874598132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874598132&partnerID=8YFLogxK

U2 - 10.3892/ijo.2013.1829

DO - 10.3892/ijo.2013.1829

M3 - Article

C2 - 23426905

AN - SCOPUS:84874598132

VL - 42

SP - 1133

EP - 1138

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 4

ER -