Human gene therapy for lung cancer

Toshiyoshi Fujiwara, F. Inoue, N. Tanaka

Research output: Contribution to journalArticle

Abstract

Lung cancer is one of the leading causes of cancer death in the world. The high mortality rate for lung cancer results from the absence of standard therapeutic strategies. Recent advances in molecular biology have demonstrated that multistep genetic alterations are involved in the carcinogenesis of human lung cancer. Human gene therapy has become a reality with the development of effective techniques for delivering the gene to the target cells. The efficacy of gene therapy for various types of genetic disease now being evaluated in clinical trials. These findings led us to develop a novel gene therapeutic strategy for human lung cancer that could either inhibit the oncogene expression or replace the tumor suppressor gene by using recombinant, replication-defective viral vectors. The article reviews recent highlights in this rapidly evolving field.

Original languageEnglish
Pages (from-to)1296-1306
Number of pages11
JournalNihon rinsho. Japanese journal of clinical medicine
Volume55
Issue number5
Publication statusPublished - 1997

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Genetic Therapy
Lung Neoplasms
Inborn Genetic Diseases
Tumor Suppressor Genes
Oncogenes
Genes
Molecular Biology
Cause of Death
Carcinogenesis
Clinical Trials
Mortality
Therapeutics
Neoplasms

Cite this

Human gene therapy for lung cancer. / Fujiwara, Toshiyoshi; Inoue, F.; Tanaka, N.

In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 55, No. 5, 1997, p. 1296-1306.

Research output: Contribution to journalArticle

Fujiwara, T, Inoue, F & Tanaka, N 1997, 'Human gene therapy for lung cancer', Nihon rinsho. Japanese journal of clinical medicine, vol. 55, no. 5, pp. 1296-1306.
Fujiwara, Toshiyoshi ; Inoue, F. ; Tanaka, N. / Human gene therapy for lung cancer. In: Nihon rinsho. Japanese journal of clinical medicine. 1997 ; Vol. 55, No. 5. pp. 1296-1306.
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