Human colon cancer cells express functional fas ligand

E. X. Ding, A. Hizuta, Y. Morimoto, T. Tanida, T. Hongo, T. Ishii, T. Yamano, T. Fujiwara, H. Twagaki, N. Tanaka

Research output: Contribution to journalArticle

Abstract

Fas ligand (FasL) belongs to the TNF superfamily. FasL is reported to be detected on activated lymphocytes and in some tissues other than lymphoid cells. We investigated expression and function of FasL on human colon cancer cells. Six colon cancer cell lines used in this experiment expressed FasL mRNA, whereas it was not detected on normal fibroblasts. FasL protein was detected by flow cytometry on DLD-1, LoVo, COLO 320DM and HCT 116 and by immunohistochemical staining in DLD-1, LoVo, HCT 116 and RPMI 4788. DLD 1, LoVo and WiDr were cytotoxic against human Fas-expressing cells. It is concluded that human colon cancer cells, at least in part, express functional FasL and are cytotoxic against Fas-expressing cells.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalBiotherapy
Volume12
Issue number1
Publication statusPublished - Jan 1 1998

Keywords

  • Apoptosis
  • Colon cancer cells
  • Fas ligand

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Ding, E. X., Hizuta, A., Morimoto, Y., Tanida, T., Hongo, T., Ishii, T., Yamano, T., Fujiwara, T., Twagaki, H., & Tanaka, N. (1998). Human colon cancer cells express functional fas ligand. Biotherapy, 12(1), 163-165.