Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains

Tomomi Takahashi, Hideki Nakagoshi, Akinori Sarai, Nobuo Nomura, Tadashi Yamamoto, Shunsuke Ishii

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The myb gene family has three members, c-myb, A-myb, and B-myb. A-myb mRNA is mainly expressed in testis and peripheral blood leukocytes. A-Myb can activate transcription from the promoter containing Myb-binding sites in all cells examined. In addition to the two domains (a DNA-binding domain and a transcriptional activation domain), two negative regulatory domains have been identified in A-Myb. These results indicate that A-Myb functions as a transcriptional activator mainly in testis and peripheral blood cells, and the regulatory mechanism of A-Myb activity is similar to that of c-Myb.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalFEBS Letters
Volume358
Issue number1
DOIs
Publication statusPublished - Jan 16 1995
Externally publishedYes

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Keywords

  • A-myb gene
  • Negative regulatory domain
  • Tissue-specific expression
  • Transcriptional activator

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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