Human α-and β-defensin immunoreactivity in oral mucoepidermoid carcinomas

Nobuyoshi Mizukawa, K. Sawaki, Hitoshi Nagatsuka, M. Kamio, Eiki Yamachika, J. Fukunaga, T. Ueno, S. Takagi, T. Sugahara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The purpose of this study was to demonstrate the immunohistochemical localization and distribution of human α-and β-defensins, peptides with antimicrobial activity, in oral mucoepidermoid carcinoma tissue. Tissue samples were embedded in paraffin and α- and β-defensins were immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells that constituted the ducts, as well as neutrophils, were positively immunostained with the anti-α-defensin antibody (HNPs). On the other hand, epidermoid cells and intermediate cells were intensely stained with the anti-β-defensin-2 (HBD-2) antibody. Mucous-secreting cells were clearly not immunostained with the anti-HBD-2 antibody. The epithelial hyperplasia region adjacent to the tumor tissues was also positively immunostained with the anti-HBD-2 antibody.

Original languageEnglish
Pages (from-to)2171-2174
Number of pages4
JournalAnticancer Research
Volume21
Issue number3 C
Publication statusPublished - 2001

Fingerprint

Mucoepidermoid Carcinoma
Defensins
Antibodies
Streptavidin
Biotin
Paraffin
Peroxidase
Hyperplasia
Anti-Idiotypic Antibodies
Neoplasms
Neutrophils
Peptides

Keywords

  • β-defensin
  • Defensin
  • HBD-2
  • Mucoepidermoid carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Human α-and β-defensin immunoreactivity in oral mucoepidermoid carcinomas. / Mizukawa, Nobuyoshi; Sawaki, K.; Nagatsuka, Hitoshi; Kamio, M.; Yamachika, Eiki; Fukunaga, J.; Ueno, T.; Takagi, S.; Sugahara, T.

In: Anticancer Research, Vol. 21, No. 3 C, 2001, p. 2171-2174.

Research output: Contribution to journalArticle

Mizukawa, N, Sawaki, K, Nagatsuka, H, Kamio, M, Yamachika, E, Fukunaga, J, Ueno, T, Takagi, S & Sugahara, T 2001, 'Human α-and β-defensin immunoreactivity in oral mucoepidermoid carcinomas', Anticancer Research, vol. 21, no. 3 C, pp. 2171-2174.
Mizukawa, Nobuyoshi ; Sawaki, K. ; Nagatsuka, Hitoshi ; Kamio, M. ; Yamachika, Eiki ; Fukunaga, J. ; Ueno, T. ; Takagi, S. ; Sugahara, T. / Human α-and β-defensin immunoreactivity in oral mucoepidermoid carcinomas. In: Anticancer Research. 2001 ; Vol. 21, No. 3 C. pp. 2171-2174.
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AU - Fukunaga, J.

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