Abstract
The purpose of this study was to demonstrate the immunohistochemical localization and distribution of human α-and β-defensins, peptides with antimicrobial activity, in oral mucoepidermoid carcinoma tissue. Tissue samples were embedded in paraffin and α- and β-defensins were immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells that constituted the ducts, as well as neutrophils, were positively immunostained with the anti-α-defensin antibody (HNPs). On the other hand, epidermoid cells and intermediate cells were intensely stained with the anti-β-defensin-2 (HBD-2) antibody. Mucous-secreting cells were clearly not immunostained with the anti-HBD-2 antibody. The epithelial hyperplasia region adjacent to the tumor tissues was also positively immunostained with the anti-HBD-2 antibody.
Original language | English |
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Pages (from-to) | 2171-2174 |
Number of pages | 4 |
Journal | Anticancer research |
Volume | 21 |
Issue number | 3 C |
Publication status | Published - 2001 |
Keywords
- Defensin
- HBD-2
- Mucoepidermoid carcinoma
- β-defensin
ASJC Scopus subject areas
- Oncology
- Cancer Research