HSP90 and its inhibitors

Huifang Hao, Yoshio Naomoto, Xiaohong Bao, Nobuyuki Watanabe, Kazufumi Sakurama, Kazuhiro Noma, Takayuki Motoki, Yasuko Tomono, Takuya Fukazawa, Yasuhiro Shirakawa, Tomoki Yamatsuji, Junji Matsuoka, Munenori Takaoka

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The HSP90 molecular chaperone family is highly conserved and expressed in various organisms ranging from prokaryotes to eukaryotes. HSP90 proteins play essential housekeeping functions, such as controlling the activity, turnover and trafficking of various proteins, promoting cell survival through maintaining the structural and functional integrity of some client proteins which control cell survival, proliferation and apoptosis, and play an important role in the progression of malignant disease. HSP90 proteins are ATP-dependent chaperones and the binding and hydrolysis of ATP are coupled to conformation changes of HSP90, which facilitate client protein folding and maturation. Many natural and synthetic molecular compounds have been proposed as promising cancer therapy via disrupting the formation of complex ATP-HSP90-client proteins.

Original languageEnglish
Pages (from-to)1483-1492
Number of pages10
JournalOncology Reports
Volume23
Issue number6
DOIs
Publication statusPublished - 2010

Fingerprint

Adenosine Triphosphate
Cell Survival
Proteins
Housekeeping
Molecular Chaperones
Protein Folding
Protein Transport
Eukaryota
Disease Progression
Hydrolysis
Cell Proliferation
Apoptosis
Neoplasms
Therapeutics

Keywords

  • Chaperone
  • Heat shock protein 90
  • Inhibitors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Hao, H., Naomoto, Y., Bao, X., Watanabe, N., Sakurama, K., Noma, K., ... Takaoka, M. (2010). HSP90 and its inhibitors. Oncology Reports, 23(6), 1483-1492. https://doi.org/10.3892/or-00000787

HSP90 and its inhibitors. / Hao, Huifang; Naomoto, Yoshio; Bao, Xiaohong; Watanabe, Nobuyuki; Sakurama, Kazufumi; Noma, Kazuhiro; Motoki, Takayuki; Tomono, Yasuko; Fukazawa, Takuya; Shirakawa, Yasuhiro; Yamatsuji, Tomoki; Matsuoka, Junji; Takaoka, Munenori.

In: Oncology Reports, Vol. 23, No. 6, 2010, p. 1483-1492.

Research output: Contribution to journalArticle

Hao, H, Naomoto, Y, Bao, X, Watanabe, N, Sakurama, K, Noma, K, Motoki, T, Tomono, Y, Fukazawa, T, Shirakawa, Y, Yamatsuji, T, Matsuoka, J & Takaoka, M 2010, 'HSP90 and its inhibitors', Oncology Reports, vol. 23, no. 6, pp. 1483-1492. https://doi.org/10.3892/or-00000787
Hao H, Naomoto Y, Bao X, Watanabe N, Sakurama K, Noma K et al. HSP90 and its inhibitors. Oncology Reports. 2010;23(6):1483-1492. https://doi.org/10.3892/or-00000787
Hao, Huifang ; Naomoto, Yoshio ; Bao, Xiaohong ; Watanabe, Nobuyuki ; Sakurama, Kazufumi ; Noma, Kazuhiro ; Motoki, Takayuki ; Tomono, Yasuko ; Fukazawa, Takuya ; Shirakawa, Yasuhiro ; Yamatsuji, Tomoki ; Matsuoka, Junji ; Takaoka, Munenori. / HSP90 and its inhibitors. In: Oncology Reports. 2010 ; Vol. 23, No. 6. pp. 1483-1492.
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