HSP70 expression in the mouse dental pulp after immediate teeth separation

Keisuke Nakano; Shinnosuke Saito; Atsushi Nabeyama; Shintaro Oishi; Masahiro Sato; Yukiko Yokoi; Naoto Osuga; Norimasa Okafuji; Toshiyuki Kawakami

doi:10.2485/jhtb.22.7

HSP70 expression in the mouse dental pulp after immediate teeth separation

Keisuke Nakano, Shinnosuke Saito, Atsushi Nabeyama, Shintaro Oishi, Masahiro Sato, Yukiko Yokoi, Naoto Osuga, Norimasa Okafuji, Toshiyuki Kawakami

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We examined the change of HSP70 expression in the mouse dental pulp which was exposed to experimental teeth separation by immunohistochemistry as a model for conservative dental treatment. Eight week-old 18 male ddY mice were used and a wedge was inserted between upper 1^st and 2^nd molars for 3 hours. In the experimental group, HSP70 expression increased in the dental pulp tissues. The expression was the greatest at 24 hours after which it gradually decreased to become similar to the level of the control group at 1 week. These results suggest that when immunohistochemical expression of HSP70 is used as an index, almost no severe damage occurs upon clinical application of a wedge insertion.

Original language	English
Pages (from-to)	7-11
Number of pages	5
Journal	Journal of Hard Tissue Biology
Volume	22
Issue number	1
DOIs	https://doi.org/10.2485/jhtb.22.7
Publication status	Published - 2013
Externally published	Yes

Keywords

Dental pulp
HSP70
Immediate teeth separation
Immunohistochemistry
Mechanical stress

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry
Biomaterials
Orthopedics and Sports Medicine
Dentistry(all)
Cell Biology

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10.2485/jhtb.22.7

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abstract = "We examined the change of HSP70 expression in the mouse dental pulp which was exposed to experimental teeth separation by immunohistochemistry as a model for conservative dental treatment. Eight week-old 18 male ddY mice were used and a wedge was inserted between upper 1st and 2nd molars for 3 hours. In the experimental group, HSP70 expression increased in the dental pulp tissues. The expression was the greatest at 24 hours after which it gradually decreased to become similar to the level of the control group at 1 week. These results suggest that when immunohistochemical expression of HSP70 is used as an index, almost no severe damage occurs upon clinical application of a wedge insertion.",

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AU - Nakano, Keisuke

AU - Saito, Shinnosuke

AU - Nabeyama, Atsushi

AU - Oishi, Shintaro

AU - Sato, Masahiro

AU - Yokoi, Yukiko

AU - Osuga, Naoto

AU - Okafuji, Norimasa

AU - Kawakami, Toshiyuki

PY - 2013

Y1 - 2013

N2 - We examined the change of HSP70 expression in the mouse dental pulp which was exposed to experimental teeth separation by immunohistochemistry as a model for conservative dental treatment. Eight week-old 18 male ddY mice were used and a wedge was inserted between upper 1st and 2nd molars for 3 hours. In the experimental group, HSP70 expression increased in the dental pulp tissues. The expression was the greatest at 24 hours after which it gradually decreased to become similar to the level of the control group at 1 week. These results suggest that when immunohistochemical expression of HSP70 is used as an index, almost no severe damage occurs upon clinical application of a wedge insertion.

AB - We examined the change of HSP70 expression in the mouse dental pulp which was exposed to experimental teeth separation by immunohistochemistry as a model for conservative dental treatment. Eight week-old 18 male ddY mice were used and a wedge was inserted between upper 1st and 2nd molars for 3 hours. In the experimental group, HSP70 expression increased in the dental pulp tissues. The expression was the greatest at 24 hours after which it gradually decreased to become similar to the level of the control group at 1 week. These results suggest that when immunohistochemical expression of HSP70 is used as an index, almost no severe damage occurs upon clinical application of a wedge insertion.

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KW - Immediate teeth separation

KW - Immunohistochemistry

KW - Mechanical stress

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HSP70 expression in the mouse dental pulp after immediate teeth separation

Abstract

Keywords

ASJC Scopus subject areas

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