How to study boron biodistribution in liver metastases from colorectal cancer

Laura Roveda, U. Prati, J. Bakeine, F. Trotta, P. Marotta, P. Valsecchi, A. Zonta, R. Nano, A. Facoetti, P. Chiari, S. Barni, T. Pinelli, S. Altieri, A. Braghieri, P. Bruschi, F. Fossati, P. Pedroni

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20 Citations (Scopus)

Abstract

The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: α particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalJournal of Chemotherapy
Volume16
Issue numberSUPPL. 5
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

Keywords

  • Boron neutron capture therapy
  • Liver metastasis

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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