Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin

Chikara Miyazaki, Naoya Ohara, Hideharu Yukitake, Masamichi Kinomoto, Kenji Matsushita, Sohkichi Matsumoto, Akio Mizuno, Takeshi Yamada

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH) skin reactions in guinea pigs immunized with live BCG or heat killed Mycobacterium tuberculosis H37Rv, and also induced lymphocyte proliferative response in mice immunized with ribosomes. In contrast, neither ribosomal proteins nor RNA alone induced both DTH skin reactions and lymphocyte proliferative responses. Particle form consisted of ribosomal proteins and RNAs might be absolutely required for the activation of immune responses.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalVaccine
Volume17
Issue number3
DOIs
Publication statusPublished - Feb 1 1999
Externally publishedYes

Keywords

  • BCG ribosomal vaccine
  • Delayed type hypersensitivity skin reactions
  • Lymphocyte proliferative responses

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Miyazaki, C., Ohara, N., Yukitake, H., Kinomoto, M., Matsushita, K., Matsumoto, S., Mizuno, A., & Yamada, T. (1999). Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin. Vaccine, 17(3), 245-251. https://doi.org/10.1016/S0264-410X(98)00191-1