Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin

Chikara Miyazaki; Naoya Ohara; Hideharu Yukitake; Masamichi Kinomoto; Kenji Matsushita; Sohkichi Matsumoto; Akio Mizuno; Takeshi Yamada

doi:10.1016/S0264-410X(98)00191-1

Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin

Chikara Miyazaki, Naoya Ohara, Hideharu Yukitake, Masamichi Kinomoto, Kenji Matsushita, Sohkichi Matsumoto, Akio Mizuno, Takeshi Yamada

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH) skin reactions in guinea pigs immunized with live BCG or heat killed Mycobacterium tuberculosis H37Rv, and also induced lymphocyte proliferative response in mice immunized with ribosomes. In contrast, neither ribosomal proteins nor RNA alone induced both DTH skin reactions and lymphocyte proliferative responses. Particle form consisted of ribosomal proteins and RNAs might be absolutely required for the activation of immune responses.

Original language	English
Pages (from-to)	245-251
Number of pages	7
Journal	Vaccine
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/S0264-410X(98)00191-1
Publication status	Published - Feb 1999
Externally published	Yes

Keywords

BCG ribosomal vaccine
Delayed type hypersensitivity skin reactions
Lymphocyte proliferative responses

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0264-410X(98)00191-1

Cite this

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title = "Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin",

abstract = "The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH) skin reactions in guinea pigs immunized with live BCG or heat killed Mycobacterium tuberculosis H37Rv, and also induced lymphocyte proliferative response in mice immunized with ribosomes. In contrast, neither ribosomal proteins nor RNA alone induced both DTH skin reactions and lymphocyte proliferative responses. Particle form consisted of ribosomal proteins and RNAs might be absolutely required for the activation of immune responses.",

keywords = "BCG ribosomal vaccine, Delayed type hypersensitivity skin reactions, Lymphocyte proliferative responses",

author = "Chikara Miyazaki and Naoya Ohara and Hideharu Yukitake and Masamichi Kinomoto and Kenji Matsushita and Sohkichi Matsumoto and Akio Mizuno and Takeshi Yamada",

year = "1999",

month = feb,

doi = "10.1016/S0264-410X(98)00191-1",

language = "English",

volume = "17",

pages = "245--251",

journal = "Vaccine",

issn = "0264-410X",

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}

TY - JOUR

T1 - Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin

AU - Miyazaki, Chikara

AU - Ohara, Naoya

AU - Yukitake, Hideharu

AU - Kinomoto, Masamichi

AU - Matsushita, Kenji

AU - Matsumoto, Sohkichi

AU - Mizuno, Akio

AU - Yamada, Takeshi

PY - 1999/2

Y1 - 1999/2

N2 - The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH) skin reactions in guinea pigs immunized with live BCG or heat killed Mycobacterium tuberculosis H37Rv, and also induced lymphocyte proliferative response in mice immunized with ribosomes. In contrast, neither ribosomal proteins nor RNA alone induced both DTH skin reactions and lymphocyte proliferative responses. Particle form consisted of ribosomal proteins and RNAs might be absolutely required for the activation of immune responses.

AB - The ribosomes from BCG strongly induced delayed type hypersensitivity (DTH) skin reactions in guinea pigs immunized with live BCG or heat killed Mycobacterium tuberculosis H37Rv, and also induced lymphocyte proliferative response in mice immunized with ribosomes. In contrast, neither ribosomal proteins nor RNA alone induced both DTH skin reactions and lymphocyte proliferative responses. Particle form consisted of ribosomal proteins and RNAs might be absolutely required for the activation of immune responses.

KW - BCG ribosomal vaccine

KW - Delayed type hypersensitivity skin reactions

KW - Lymphocyte proliferative responses

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U2 - 10.1016/S0264-410X(98)00191-1

DO - 10.1016/S0264-410X(98)00191-1

M3 - Article

C2 - 9987160

AN - SCOPUS:0344474533

SN - 0264-410X

VL - 17

SP - 245

EP - 251

JO - Vaccine

JF - Vaccine

IS - 3

ER -

Host immune responses to ribosome, ribosomal proteins, and RNA from Mycobacterium bovis bacille de Calmette-Guerin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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