Host defensive functions in a family manifesting early-onset periodontitis

Hideo Arai, Toshihiro Chihara, Keiso Takahashi, Atsushi Nagai, Isao Akutsu, Shogo Takashiba, Fusanori Nishimura, Hidemi Kurihara, Yoji Murayama

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11 Citations (Scopus)

Abstract

FAMILY CASE STUDIES HELP US IDENTIFY host risk factors in periodontal disease. In this study we examine a family consisting of a mother (40 years old, with rapidly progressive periodontitis), her elder daughter (14 years old, with localized juvenile periodontitis), and younger daughter (13 years old, with simple gingivitis). We examined 1) the peripheral neutrophil functions (chemotactic migration, phagocytosis, superoxide production); 2) lymphocyte functions (proliferative activity and cytokine productivity of T cells. immunoglobulin [Ig] M productivity of B cells when stimulated with pokeweed mitogen); 3) phenotypic analyses of peripheral lymphocyte subpopulations; 4) serum IgG antibody titers against periodontopathic bacteria; and 5) serological type of HLA class II. All the subjects exhibited high T4/T8 ratios due to high percentage of CD4-positive cells, showed high IgG titers to Actinobacillus actinomycetemcomitans, and had a HLA DQw1 in common. The mother showed a slight deficiency of neutrophil chemotactic migration to N-formyl methyonyl leucyl phenylalanin (fMLP), raised interleukin-2 productivity of T cell, and high levels of IgG titers to Porphyromonus gingivalis and Fusobacterium nucleatum. Both daughters showed weak T cell proliferative response to anti-CD3 monoclonal antibody and low IgM productivity. Low lymphocyte responsiveness may be involved in the pathogenesis of periodontal disease of these daughters; therefore, the lymphocyte dysfunctions shown should be considered in relation to the progression of periodontal disease.

Original languageEnglish
Pages (from-to)433-442
Number of pages10
JournalJournal of periodontology
Volume67
Issue number4
DOIs
Publication statusPublished - Apr 1996

Keywords

  • Family case study
  • Lymphocyte profile
  • Neutrophils
  • Periodontitis, early onset
  • Periodontitis, juvenile
  • Periodontitis, rapidly progressive
  • Risk factors

ASJC Scopus subject areas

  • Periodontics

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  • Cite this

    Arai, H., Chihara, T., Takahashi, K., Nagai, A., Akutsu, I., Takashiba, S., Nishimura, F., Kurihara, H., & Murayama, Y. (1996). Host defensive functions in a family manifesting early-onset periodontitis. Journal of periodontology, 67(4), 433-442. https://doi.org/10.1902/jop.1996.67.4.433