Host and viral RNA-binding proteins involved in membrane targeting, replication and intercellular movement of plant RNA virus genomes

Kiwamu Hyodo, Masanori Kaido, Tetsuro Okuno

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Many plant viruses have positive-strand RNA [(+)RNA] as their genome. Therefore, it is not surprising that RNA-binding proteins (RBPs) play important roles during (+)RNA virus infection in host plants. Increasing evidence demonstrates that viral and host RBPs play critical roles in multiple steps of the viral life cycle, including translation and replication of viral genomic RNAs, and their intra- and intercellular movement. Although studies focusing on the RNA-binding activities of viral and host proteins, and their associations with membrane targeting, and intercellular movement of viral genomes have been limited to a few viruses, these studies have provided important insights into the molecular mechanisms underlying the replication and movement of viral genomic RNAs. In this review, we briefly overview the currently defined roles of viral and host RBPs whose RNA-binding activity have been confirmed experimentally in association with their membrane targeting, and intercellular movement of plant RNA virus genomes.

Original languageEnglish
Article number321
JournalFrontiers in Plant Science
Volume5
Issue numberJUL
DOIs
Publication statusPublished - Jul 7 2014
Externally publishedYes

Keywords

  • Cell-to-cell movement
  • Cellular membrane
  • RNA replication
  • RNA virus
  • RNA-binding protein

ASJC Scopus subject areas

  • Plant Science

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