Hormonal characteristics of primary aldosteronism due to unilateral adrenal hyperplasia

Fumio Otsuka, F. Otsuka-Misunaga, S. Koyama, H. Yamanari, T. Ogura, T. Ohe, Hirofumi Makino

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A case of unilateral adrenocortical hyperplasia is presented. A 46-year-old woman with a 7-year history of hypertension and a 1-year-history of hypokalemia was diagnosed with primary aldosteronism. Computed tomography, magnetic resonance imaging, venous sampling and adosterol scintigraphy exhibited a functioning left adrenal mass. The plasma aldosterone concentration increased markedly when furosemide with upright posture and either captopril or adrenocorticotropin were administered. Plasma renin activity was suppressed below the detectable range. Aldosterone secretion displayed a circadian rhythm and was not suppressed by dexamethasone administration. The resected left adrenal mass was pathologically diagnosed as adrenocortical nodular hyperplasia. Unilateral adrenal hyperplasia involving the zona glomerulosa rarely has been reported, with varying and incompletely characterized hormonal characteristics. This case report and literature review suggest unilateral adrenal hyperplasia as a rare cause of hyperaldosteronism with characteristies intermediate between idiopathie hyperaldosteronism and aldosterone-producing adrenocortical adenoma, resembling the functional features of the adenoma more closely.

Original languageEnglish
Pages (from-to)531-536
Number of pages6
JournalJournal of Endocrinological Investigation
Volume21
Issue number8
Publication statusPublished - Sep 1998

Fingerprint

Hyperaldosteronism
Hyperplasia
Aldosterone
Adosterol
Adrenocortical Adenoma
Zona Glomerulosa
Hypokalemia
Captopril
Furosemide
Circadian Rhythm
Posture
Renin
Radionuclide Imaging
Adenoma
Adrenocorticotropic Hormone
Dexamethasone
Tomography
Magnetic Resonance Imaging
Hypertension

Keywords

  • Hypertension
  • Hypokalemia
  • Primary aldosteronism
  • Unilateral adrenal hyperplasia

ASJC Scopus subject areas

  • Endocrinology

Cite this

Hormonal characteristics of primary aldosteronism due to unilateral adrenal hyperplasia. / Otsuka, Fumio; Otsuka-Misunaga, F.; Koyama, S.; Yamanari, H.; Ogura, T.; Ohe, T.; Makino, Hirofumi.

In: Journal of Endocrinological Investigation, Vol. 21, No. 8, 09.1998, p. 531-536.

Research output: Contribution to journalArticle

Otsuka, F, Otsuka-Misunaga, F, Koyama, S, Yamanari, H, Ogura, T, Ohe, T & Makino, H 1998, 'Hormonal characteristics of primary aldosteronism due to unilateral adrenal hyperplasia', Journal of Endocrinological Investigation, vol. 21, no. 8, pp. 531-536.
Otsuka F, Otsuka-Misunaga F, Koyama S, Yamanari H, Ogura T, Ohe T et al. Hormonal characteristics of primary aldosteronism due to unilateral adrenal hyperplasia. Journal of Endocrinological Investigation. 1998 Sep;21(8):531-536.
Otsuka, Fumio ; Otsuka-Misunaga, F. ; Koyama, S. ; Yamanari, H. ; Ogura, T. ; Ohe, T. ; Makino, Hirofumi. / Hormonal characteristics of primary aldosteronism due to unilateral adrenal hyperplasia. In: Journal of Endocrinological Investigation. 1998 ; Vol. 21, No. 8. pp. 531-536.
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