Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine chromosome 1

Yasunori Ohba, Hitoshi Kitagawa, Katsuya Kitoh, Sachiyo Asahina, Kaori Nishimori, Kazuhiro Yoneda, Tetsuo Kunieda, Yoshihide Sasaki

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Abstract

Renal tubular dysplasia is a hereditary disease of Japanese black cattle showing renal failure and growth retardation with an autosomal recessive trait. In the present study, we mapped the locus responsible for the disease (RTD) by linkage analysis with an inbred paternal half-sib pedigree obtained from commercial herds. By analyzing segregation of microsatellite markers in the half-sibs, significant linkage was observed between the RTD locus and markers on bovine Chromosome (Chr) 1 with the highest lod score of 11.4. Homozygosity mapping with the inbred pedigree further defined the localization of the RTD locus in a 4-cM region between microsatellite markers BMS4003 and INRA119. Mapping of the RTD locus on bovine Chr 1 will facilitate cloning and characterization of the gene responsible for this disease.

Original languageEnglish
Pages (from-to)316-319
Number of pages4
JournalMammalian Genome
Volume11
Issue number4
DOIs
Publication statusPublished - 2000

Fingerprint

Chromosomes, Human, Pair 1
Kidney
Pedigree
Microsatellite Repeats
Lod Score
Inborn Genetic Diseases
Renal Insufficiency
Organism Cloning
Growth
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Ohba, Y., Kitagawa, H., Kitoh, K., Asahina, S., Nishimori, K., Yoneda, K., ... Sasaki, Y. (2000). Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine chromosome 1. Mammalian Genome, 11(4), 316-319. https://doi.org/10.1007/s003350010058

Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine chromosome 1. / Ohba, Yasunori; Kitagawa, Hitoshi; Kitoh, Katsuya; Asahina, Sachiyo; Nishimori, Kaori; Yoneda, Kazuhiro; Kunieda, Tetsuo; Sasaki, Yoshihide.

In: Mammalian Genome, Vol. 11, No. 4, 2000, p. 316-319.

Research output: Contribution to journalArticle

Ohba, Y, Kitagawa, H, Kitoh, K, Asahina, S, Nishimori, K, Yoneda, K, Kunieda, T & Sasaki, Y 2000, 'Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine chromosome 1', Mammalian Genome, vol. 11, no. 4, pp. 316-319. https://doi.org/10.1007/s003350010058
Ohba, Yasunori ; Kitagawa, Hitoshi ; Kitoh, Katsuya ; Asahina, Sachiyo ; Nishimori, Kaori ; Yoneda, Kazuhiro ; Kunieda, Tetsuo ; Sasaki, Yoshihide. / Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine chromosome 1. In: Mammalian Genome. 2000 ; Vol. 11, No. 4. pp. 316-319.
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