HLA genetics for diagnosis of susceptibility to early-onset periodontitis

Shogo Takashiba, Hideki Ohyama, Kosuke Oyaizu, Nahoko Kogoe-Kato, Yoji Murayama

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Human leukocyte antigens (HLA) are essential in the recognition of foreign antigens in humoral immune response, which is genetically predetermined. Susceptibility to certain diseases that involve the immune response has been studied in relation to distinct HLA types. Although some diseases have been found to correlate to specific HLA loci positively, it has been difficult to isolate HLA types that predispose patients to periodontal destruction. Here, we review the current knowledge and recent advances in HLA genetics and its biology, which determine susceptibility to early-onset periodontitis (EOP). The HLA-DRB1*1501-DQB1*0602 genotype has been found with increasing frequency in EOP patients. This HLA genotype expresses aspartic acid at position 57 and glycine at position 70 on the DQβ chain, suggesting a capability to bind certain bacterial antigens. The T cell response against the outer membrane protein (Ag53) of Porphyromonas gingivalis was examined via this HLA genotype. Strong T cell response against Ag53 p141 161 was inhibited partially by anti-DR antibody, but not by anti-DQ antibody. Possible host and bacterial peptides capable of binding DRB1*1501 were elucidated when the peptide sequence was compared to gene and protein databases. These results suggest that patients who have the HLA-DRB1*1501-DOB1*0602 genotype may have an accelerated T cell response to certain periodontopathic bacteria such as P. gingivalis in hyperimmune reactions and thus increased susceptibility to EOP.

Original languageEnglish
Pages (from-to)374-378
Number of pages5
JournalJournal of Periodontal Research
Volume34
Issue number7
DOIs
Publication statusPublished - Oct 1999

Keywords

  • Early-onset periodontitis
  • Human leukocyte antigen (HLA)
  • Periodontal disease
  • Susceptibility

ASJC Scopus subject areas

  • Periodontics

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