HIV-associated immune complex kidney disease with C3-dominant deposition induced by HIV infection after treatment of IgA nephropathy

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Abstract

A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated.

Original languageEnglish
Pages (from-to)3001-3007
Number of pages7
JournalInternal Medicine
Volume58
Issue number20
DOIs
Publication statusPublished - Jan 1 2019

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Immune Complex Diseases
Kidney Diseases
Virus Diseases
Immunoglobulin A
HIV
Hematuria
Proteinuria
Biopsy
Pancytopenia
Urinalysis
Tonsillectomy
Methylprednisolone
Therapeutics
Glomerulonephritis
Viral Load
Kidney
Antibodies

Keywords

  • Complement activation
  • Human immunodeficiency virus
  • Renal biopsy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "HIV-associated immune complex kidney disease with C3-dominant deposition induced by HIV infection after treatment of IgA nephropathy",
abstract = "A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated.",
keywords = "Complement activation, Human immunodeficiency virus, Renal biopsy",
author = "Chieko Kawakita and Masaru Kinomura and Nozomu Otaka and Masashi Kitagawa and Hitoshi Sugiyama and Nobuchika Kusano and Masashi Mizuno and Jun Wada",
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T1 - HIV-associated immune complex kidney disease with C3-dominant deposition induced by HIV infection after treatment of IgA nephropathy

AU - Kawakita, Chieko

AU - Kinomura, Masaru

AU - Otaka, Nozomu

AU - Kitagawa, Masashi

AU - Sugiyama, Hitoshi

AU - Kusano, Nobuchika

AU - Mizuno, Masashi

AU - Wada, Jun

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated.

AB - A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated.

KW - Complement activation

KW - Human immunodeficiency virus

KW - Renal biopsy

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