HIV-1 Inhibits Long-Term Potentiation and Attenuates Spatial Learning

Sheng Tian Li, Masayuki Matsushita, Akiyoshi Moriwaki, Yasunori Saheki, Yun Fei Lu, Kazuhito Tomizawa, Hai Yan Wu, Hiroaki Terada, Hideki Matsui

Research output: Contribution to journalArticle

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Abstract

Although memory deficits have been dearly documented in patients with human immunodeficiency virus type-1 (HIV-1) infection, the physiological basis of this dysfunction is poorly understood. We focused on Tat, a viral protein released from HIV-1-infected cells and investigated its effect on spatial learning in adult mice. An intracerebroventricular injection of Tat leads to attenuation of spatial learning accompanied by suppression of long-term potentiation (LTP), the cellular basis of spatial learning, in hippocampal cornu ammonis 1 pyramidal neurons. Tat facilitates extrasynaptic but not synaptic N-methyl-D-aspartate (NMDA) receptor activity. Taken together, these data provide strong evidence that the Tat pathway underlies the development of memory dysfunction in patients with HIV-1 infection and suggest a causal relationship between Tat, the facilitation of extrasynaptic NMDA receptor activity, inhibition of LTP, and attenuation of spatial learning.

Original languageEnglish
Pages (from-to)362-371
Number of pages10
JournalAnnals of Neurology
Volume55
Issue number3
DOIs
Publication statusPublished - Mar 2004

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Long-Term Potentiation
HIV-1
Virus Diseases
N-Methyl-D-Aspartate Receptors
Pyramidal Cells
Memory Disorders
Viral Proteins
Hippocampus
Injections
Spatial Learning

ASJC Scopus subject areas

  • Neuroscience(all)

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HIV-1 Inhibits Long-Term Potentiation and Attenuates Spatial Learning. / Li, Sheng Tian; Matsushita, Masayuki; Moriwaki, Akiyoshi; Saheki, Yasunori; Lu, Yun Fei; Tomizawa, Kazuhito; Wu, Hai Yan; Terada, Hiroaki; Matsui, Hideki.

In: Annals of Neurology, Vol. 55, No. 3, 03.2004, p. 362-371.

Research output: Contribution to journalArticle

Li, ST, Matsushita, M, Moriwaki, A, Saheki, Y, Lu, YF, Tomizawa, K, Wu, HY, Terada, H & Matsui, H 2004, 'HIV-1 Inhibits Long-Term Potentiation and Attenuates Spatial Learning', Annals of Neurology, vol. 55, no. 3, pp. 362-371. https://doi.org/10.1002/ana.10844
Li, Sheng Tian ; Matsushita, Masayuki ; Moriwaki, Akiyoshi ; Saheki, Yasunori ; Lu, Yun Fei ; Tomizawa, Kazuhito ; Wu, Hai Yan ; Terada, Hiroaki ; Matsui, Hideki. / HIV-1 Inhibits Long-Term Potentiation and Attenuates Spatial Learning. In: Annals of Neurology. 2004 ; Vol. 55, No. 3. pp. 362-371.
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