Histopathological safety evaluation of newly-developed MgO sealer

Keisuke Nakano, M. Tomida, M. Sato, S. Matsuura, A. Yamamoto, E. Kasahara, Toshiyuki Kawakami

Research output: Contribution to journalArticle

Abstract

We aimed to evaluate the subcutaneous tissue reaction to a newly-developed MgO Sealer for root canals. We injected the experimental material and three existing control materials into the dorsal area of 43 male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding sites was removed and histopathological examination was performed. The results demonstrate that the basic histopathological reaction is the formation of fibrous capsules consisting of granulation tissue around the experimental and control embedded materials. Based on our results, we believe that the newly-developed MgO Sealer is as safe as the existing control materials and can be considered for dental use as a root canal sealer.

Original languageEnglish
Pages (from-to)526-530
Number of pages5
JournalEuropean Journal of Medical Research
Volume16
Issue number12
Publication statusPublished - Dec 2 2011
Externally publishedYes

Fingerprint

Dental Pulp Cavity
Tissue Embedding
Safety
Granulation Tissue
Subcutaneous Tissue
Capsules
Tooth
canals sealer

Keywords

  • Histopathological evaluation
  • Magnesium oxide
  • Root canal sealer
  • Tissue reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nakano, K., Tomida, M., Sato, M., Matsuura, S., Yamamoto, A., Kasahara, E., & Kawakami, T. (2011). Histopathological safety evaluation of newly-developed MgO sealer. European Journal of Medical Research, 16(12), 526-530.

Histopathological safety evaluation of newly-developed MgO sealer. / Nakano, Keisuke; Tomida, M.; Sato, M.; Matsuura, S.; Yamamoto, A.; Kasahara, E.; Kawakami, Toshiyuki.

In: European Journal of Medical Research, Vol. 16, No. 12, 02.12.2011, p. 526-530.

Research output: Contribution to journalArticle

Nakano, K, Tomida, M, Sato, M, Matsuura, S, Yamamoto, A, Kasahara, E & Kawakami, T 2011, 'Histopathological safety evaluation of newly-developed MgO sealer', European Journal of Medical Research, vol. 16, no. 12, pp. 526-530.
Nakano K, Tomida M, Sato M, Matsuura S, Yamamoto A, Kasahara E et al. Histopathological safety evaluation of newly-developed MgO sealer. European Journal of Medical Research. 2011 Dec 2;16(12):526-530.
Nakano, Keisuke ; Tomida, M. ; Sato, M. ; Matsuura, S. ; Yamamoto, A. ; Kasahara, E. ; Kawakami, Toshiyuki. / Histopathological safety evaluation of newly-developed MgO sealer. In: European Journal of Medical Research. 2011 ; Vol. 16, No. 12. pp. 526-530.
@article{8ee0d0883cd5438baf639576b9b90256,
title = "Histopathological safety evaluation of newly-developed MgO sealer",
abstract = "We aimed to evaluate the subcutaneous tissue reaction to a newly-developed MgO Sealer for root canals. We injected the experimental material and three existing control materials into the dorsal area of 43 male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding sites was removed and histopathological examination was performed. The results demonstrate that the basic histopathological reaction is the formation of fibrous capsules consisting of granulation tissue around the experimental and control embedded materials. Based on our results, we believe that the newly-developed MgO Sealer is as safe as the existing control materials and can be considered for dental use as a root canal sealer.",
keywords = "Histopathological evaluation, Magnesium oxide, Root canal sealer, Tissue reaction",
author = "Keisuke Nakano and M. Tomida and M. Sato and S. Matsuura and A. Yamamoto and E. Kasahara and Toshiyuki Kawakami",
year = "2011",
month = "12",
day = "2",
language = "English",
volume = "16",
pages = "526--530",
journal = "European Journal of Medical Research",
issn = "0949-2321",
publisher = "BioMed Central",
number = "12",

}

TY - JOUR

T1 - Histopathological safety evaluation of newly-developed MgO sealer

AU - Nakano, Keisuke

AU - Tomida, M.

AU - Sato, M.

AU - Matsuura, S.

AU - Yamamoto, A.

AU - Kasahara, E.

AU - Kawakami, Toshiyuki

PY - 2011/12/2

Y1 - 2011/12/2

N2 - We aimed to evaluate the subcutaneous tissue reaction to a newly-developed MgO Sealer for root canals. We injected the experimental material and three existing control materials into the dorsal area of 43 male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding sites was removed and histopathological examination was performed. The results demonstrate that the basic histopathological reaction is the formation of fibrous capsules consisting of granulation tissue around the experimental and control embedded materials. Based on our results, we believe that the newly-developed MgO Sealer is as safe as the existing control materials and can be considered for dental use as a root canal sealer.

AB - We aimed to evaluate the subcutaneous tissue reaction to a newly-developed MgO Sealer for root canals. We injected the experimental material and three existing control materials into the dorsal area of 43 male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding sites was removed and histopathological examination was performed. The results demonstrate that the basic histopathological reaction is the formation of fibrous capsules consisting of granulation tissue around the experimental and control embedded materials. Based on our results, we believe that the newly-developed MgO Sealer is as safe as the existing control materials and can be considered for dental use as a root canal sealer.

KW - Histopathological evaluation

KW - Magnesium oxide

KW - Root canal sealer

KW - Tissue reaction

UR - http://www.scopus.com/inward/record.url?scp=84255167009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84255167009&partnerID=8YFLogxK

M3 - Article

C2 - 22112358

AN - SCOPUS:84255167009

VL - 16

SP - 526

EP - 530

JO - European Journal of Medical Research

JF - European Journal of Medical Research

SN - 0949-2321

IS - 12

ER -