TY - JOUR
T1 - Histopathological analysis of anaplastic thyroid carcinoma cases with long-term survival
T2 - A report from the anaplastic thyroid carcinoma research consortium of Japan
AU - Hirokawa, Mitsuyoshi
AU - Sugitani, Iwao
AU - Kakudo, Kennichi
AU - Sakamoto, Atsuhiko
AU - Higashiyama, Takuya
AU - Sugino, Kiminori
AU - Toda, Kazuhisa
AU - Ogasawara, Satoshi
AU - Yoshimoto, Seiichi
AU - Hasegawa, Yasuhisa
AU - Imai, Tsuneo
AU - Onoda, Naoyoshi
AU - Orita, Yorihisa
AU - Kammori, Makoto
AU - Fujimori, Keisei
AU - Yamada, Hiroyuki
N1 - Publisher Copyright:
© The Japan Endocrine Society.
PY - 2016
Y1 - 2016
N2 - The aim of this study was to clarify the histopathological features of anaplastic thyroid carcinoma in patients who achieved long-term survival. We reviewed 88 anaplastic thyroid carcinoma cases in which the patient survived less than 3 months (short-term survival), and 68 anaplastic thyroid carcinoma cases in which the patient survived more than one year (long-term survival) from the database of the Anaplastic Thyroid Carcinoma Research Consortium of Japan. We examined these cases both histologically and immunohistochemically. Six (6.8%) short-term survival cases and 27 (39.7%) long-term survival cases were considered not to be anaplastic thyroid carcinoma after central review. Of these, 12 were revised to papillary carcinoma with squamous cell carcinoma. In cases without chemotherapy, long-term survival was significantly more common if there was a pre-existing tumor, epithelial growth, or lymphocytic infiltration, and short-term survival was more common if neutrophilic infiltration was present. In cases with chemotherapy, long-term survival was significantly more common if epithelial growth or a squamous cell carcinoma component was present, whereas short-term survival was more common in cases with rhabdoid cells. Immunohistochemical results were not related to survival. Some long-term survival cases showed histological findings other than those typically associated with anaplastic thyroid carcinoma. The presence of a pre-existing tumor, epithelial growth, a squamous cell carcinoma component, no neutrophilic infiltration and lymphocytic infiltration may therefore be favorable prognostic factors in anaplastic thyroid carcinoma.
AB - The aim of this study was to clarify the histopathological features of anaplastic thyroid carcinoma in patients who achieved long-term survival. We reviewed 88 anaplastic thyroid carcinoma cases in which the patient survived less than 3 months (short-term survival), and 68 anaplastic thyroid carcinoma cases in which the patient survived more than one year (long-term survival) from the database of the Anaplastic Thyroid Carcinoma Research Consortium of Japan. We examined these cases both histologically and immunohistochemically. Six (6.8%) short-term survival cases and 27 (39.7%) long-term survival cases were considered not to be anaplastic thyroid carcinoma after central review. Of these, 12 were revised to papillary carcinoma with squamous cell carcinoma. In cases without chemotherapy, long-term survival was significantly more common if there was a pre-existing tumor, epithelial growth, or lymphocytic infiltration, and short-term survival was more common if neutrophilic infiltration was present. In cases with chemotherapy, long-term survival was significantly more common if epithelial growth or a squamous cell carcinoma component was present, whereas short-term survival was more common in cases with rhabdoid cells. Immunohistochemical results were not related to survival. Some long-term survival cases showed histological findings other than those typically associated with anaplastic thyroid carcinoma. The presence of a pre-existing tumor, epithelial growth, a squamous cell carcinoma component, no neutrophilic infiltration and lymphocytic infiltration may therefore be favorable prognostic factors in anaplastic thyroid carcinoma.
KW - Anaplastic thyroid carcinoma
KW - Histopathology
KW - Long-term survival
KW - Prognosis
KW - Rhabdoid cell
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U2 - 10.1507/endocrj.EJ15-0705
DO - 10.1507/endocrj.EJ15-0705
M3 - Article
C2 - 26842589
AN - SCOPUS:84971441878
VL - 63
SP - 441
EP - 447
JO - Endocrine Journal
JF - Endocrine Journal
SN - 0918-8959
IS - 5
ER -