Histopathologic study of the temporal bones and eustachian tubes of children with cholesterol granuloma

Makoto Miura, Isamu Sando, Yorihisa Orita, Barry E. Hirsch

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Six temporal bone-eustachian tube (ET) specimens with cholesterol granuloma (CG), obtained from 6 children 6 months to 15 years of age, were studied histopathologically to obtain further information about the pathogenesis of CG. We observed CG in the mastoid air cells in 5 ears, the mastoid antrum in 1 ear, the aditus ad antrum in 2 ears, and the epitympanum in 1 ear. All 6 cases exhibited a large amount of remaining mesenchyme that was in continuity with the hematopoietic bone marrow in the locations in which CG was present. All cases demonstrated otitis media with effusion and inflammation of the ET. Apparent morphological abnormalities of the ET and its associated structures, including hypoplastic ET cartilage and an abnormal tensor veli palatini muscle, were noted in 3 of the 6 cases. Furthermore, the posterior cartilaginous portion of the ET that includes its narrowest portion was completely filled with effusion in 2 of the 3 cases with the ET anomaly. The findings obtained were compared with data from age- matched control cases. Our results suggest that the source of erythrocytes in the remaining mesenchyme is the hematopoietic bone marrow. The pathogenesis of CG in children is likely promoted by ET dysfunction resulting in failure of ventilation of the middle ear.

Original languageEnglish
Pages (from-to)609-615
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Volume111
Issue number7
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Eustachian Tube
Temporal Bone
Granuloma
Cholesterol
Ear
Mastoid
Mesoderm
Bone Marrow
Middle Ear Ventilation
Otitis Media with Effusion
Cartilage
Erythrocytes
Air
Inflammation
Muscles

Keywords

  • Cholesterol granuloma
  • Eustachian tube
  • Histopathology
  • Mesenchyme
  • Temporal bone

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Histopathologic study of the temporal bones and eustachian tubes of children with cholesterol granuloma. / Miura, Makoto; Sando, Isamu; Orita, Yorihisa; Hirsch, Barry E.

In: Annals of Otology, Rhinology and Laryngology, Vol. 111, No. 7, 2002, p. 609-615.

Research output: Contribution to journalArticle

Miura, Makoto ; Sando, Isamu ; Orita, Yorihisa ; Hirsch, Barry E. / Histopathologic study of the temporal bones and eustachian tubes of children with cholesterol granuloma. In: Annals of Otology, Rhinology and Laryngology. 2002 ; Vol. 111, No. 7. pp. 609-615.
@article{1a28e9bcba7643d693bdaf91bc80eeff,
title = "Histopathologic study of the temporal bones and eustachian tubes of children with cholesterol granuloma",
abstract = "Six temporal bone-eustachian tube (ET) specimens with cholesterol granuloma (CG), obtained from 6 children 6 months to 15 years of age, were studied histopathologically to obtain further information about the pathogenesis of CG. We observed CG in the mastoid air cells in 5 ears, the mastoid antrum in 1 ear, the aditus ad antrum in 2 ears, and the epitympanum in 1 ear. All 6 cases exhibited a large amount of remaining mesenchyme that was in continuity with the hematopoietic bone marrow in the locations in which CG was present. All cases demonstrated otitis media with effusion and inflammation of the ET. Apparent morphological abnormalities of the ET and its associated structures, including hypoplastic ET cartilage and an abnormal tensor veli palatini muscle, were noted in 3 of the 6 cases. Furthermore, the posterior cartilaginous portion of the ET that includes its narrowest portion was completely filled with effusion in 2 of the 3 cases with the ET anomaly. The findings obtained were compared with data from age- matched control cases. Our results suggest that the source of erythrocytes in the remaining mesenchyme is the hematopoietic bone marrow. The pathogenesis of CG in children is likely promoted by ET dysfunction resulting in failure of ventilation of the middle ear.",
keywords = "Cholesterol granuloma, Eustachian tube, Histopathology, Mesenchyme, Temporal bone",
author = "Makoto Miura and Isamu Sando and Yorihisa Orita and Hirsch, {Barry E.}",
year = "2002",
language = "English",
volume = "111",
pages = "609--615",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "7",

}

TY - JOUR

T1 - Histopathologic study of the temporal bones and eustachian tubes of children with cholesterol granuloma

AU - Miura, Makoto

AU - Sando, Isamu

AU - Orita, Yorihisa

AU - Hirsch, Barry E.

PY - 2002

Y1 - 2002

N2 - Six temporal bone-eustachian tube (ET) specimens with cholesterol granuloma (CG), obtained from 6 children 6 months to 15 years of age, were studied histopathologically to obtain further information about the pathogenesis of CG. We observed CG in the mastoid air cells in 5 ears, the mastoid antrum in 1 ear, the aditus ad antrum in 2 ears, and the epitympanum in 1 ear. All 6 cases exhibited a large amount of remaining mesenchyme that was in continuity with the hematopoietic bone marrow in the locations in which CG was present. All cases demonstrated otitis media with effusion and inflammation of the ET. Apparent morphological abnormalities of the ET and its associated structures, including hypoplastic ET cartilage and an abnormal tensor veli palatini muscle, were noted in 3 of the 6 cases. Furthermore, the posterior cartilaginous portion of the ET that includes its narrowest portion was completely filled with effusion in 2 of the 3 cases with the ET anomaly. The findings obtained were compared with data from age- matched control cases. Our results suggest that the source of erythrocytes in the remaining mesenchyme is the hematopoietic bone marrow. The pathogenesis of CG in children is likely promoted by ET dysfunction resulting in failure of ventilation of the middle ear.

AB - Six temporal bone-eustachian tube (ET) specimens with cholesterol granuloma (CG), obtained from 6 children 6 months to 15 years of age, were studied histopathologically to obtain further information about the pathogenesis of CG. We observed CG in the mastoid air cells in 5 ears, the mastoid antrum in 1 ear, the aditus ad antrum in 2 ears, and the epitympanum in 1 ear. All 6 cases exhibited a large amount of remaining mesenchyme that was in continuity with the hematopoietic bone marrow in the locations in which CG was present. All cases demonstrated otitis media with effusion and inflammation of the ET. Apparent morphological abnormalities of the ET and its associated structures, including hypoplastic ET cartilage and an abnormal tensor veli palatini muscle, were noted in 3 of the 6 cases. Furthermore, the posterior cartilaginous portion of the ET that includes its narrowest portion was completely filled with effusion in 2 of the 3 cases with the ET anomaly. The findings obtained were compared with data from age- matched control cases. Our results suggest that the source of erythrocytes in the remaining mesenchyme is the hematopoietic bone marrow. The pathogenesis of CG in children is likely promoted by ET dysfunction resulting in failure of ventilation of the middle ear.

KW - Cholesterol granuloma

KW - Eustachian tube

KW - Histopathology

KW - Mesenchyme

KW - Temporal bone

UR - http://www.scopus.com/inward/record.url?scp=0036314640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036314640&partnerID=8YFLogxK

M3 - Article

C2 - 12126017

AN - SCOPUS:0036314640

VL - 111

SP - 609

EP - 615

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 7

ER -