Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease

Shin Kariya, Sebahattin Cureoglu, Hisaki Fukushima, Takeshi Kusunoki, Patricia A. Schachern, Kazunori Nishizaki, Michael M. Paparella

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

HYPOTHESIS: To disclose the histopathologic findings in the contralateral temporal bone in unilateral Ménière's disease. BACKGROUND: Several functional studies reported abnormal findings in the contralateral ears in patients with unilateral Ménière's disease. METHODS: This study involved quantitative analysis, including the number of spiral ganglion cells, the loss of cochlear hair cells, the area of stria vascularis, and the density of fibrocytes in the spiral ligament. It included 14 temporal bones from 7 subjects with bilateral Ménière's disease, 30 temporal bones from 15 subjects with unilateral Ménière's disease, and 17 age-matched normal control temporal bones from 12 subjects. RESULTS: The mean number of spiral ganglion cells in the contralateral temporal bones in patients with unilateral Ménière's disease was 17,376.0 and was significantly lower than that in normal controls. The mean loss of inner and outer hair cells in the contralateral temporal bones in patients with unilateral Ménière's disease was significantly greater than that in normal controls in all turns. The stria vascularis was severely atrophic and degenerated in patients with Ménière's disease. The mean area of stria vascularis in contralateral temporal bones in patients with unilateral Ménière's disease was significantly smaller than normal controls. There was no significant difference in the density of fibrocytes in the spiral ligament between the diseased side and the contralateral side in patients with unilateral Ménière's disease and between normal control and contralateral side. CONCLUSION: The contralateral inner ear in patients with unilateral Ménière's disease has significantly more damage compared with inner ears of normal controls.

Original languageEnglish
Pages (from-to)1063-1068
Number of pages6
JournalOtology and Neurotology
Volume28
Issue number8
DOIs
Publication statusPublished - Dec 2007

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Temporal Bone
Stria Vascularis
Spiral Ligament of Cochlea
Spiral Ganglion
Inner Ear
Outer Auditory Hair Cells
Inner Auditory Hair Cells
Auditory Hair Cells
Ear

Keywords

  • Contralateral ear
  • Histopathology
  • Ménière's disease
  • Vertigo

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Neuroscience(all)

Cite this

Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease. / Kariya, Shin; Cureoglu, Sebahattin; Fukushima, Hisaki; Kusunoki, Takeshi; Schachern, Patricia A.; Nishizaki, Kazunori; Paparella, Michael M.

In: Otology and Neurotology, Vol. 28, No. 8, 12.2007, p. 1063-1068.

Research output: Contribution to journalArticle

Kariya, Shin ; Cureoglu, Sebahattin ; Fukushima, Hisaki ; Kusunoki, Takeshi ; Schachern, Patricia A. ; Nishizaki, Kazunori ; Paparella, Michael M. / Histopathologic changes of contralateral human temporal bone in unilateral Ménière's disease. In: Otology and Neurotology. 2007 ; Vol. 28, No. 8. pp. 1063-1068.
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abstract = "HYPOTHESIS: To disclose the histopathologic findings in the contralateral temporal bone in unilateral M{\'e}ni{\`e}re's disease. BACKGROUND: Several functional studies reported abnormal findings in the contralateral ears in patients with unilateral M{\'e}ni{\`e}re's disease. METHODS: This study involved quantitative analysis, including the number of spiral ganglion cells, the loss of cochlear hair cells, the area of stria vascularis, and the density of fibrocytes in the spiral ligament. It included 14 temporal bones from 7 subjects with bilateral M{\'e}ni{\`e}re's disease, 30 temporal bones from 15 subjects with unilateral M{\'e}ni{\`e}re's disease, and 17 age-matched normal control temporal bones from 12 subjects. RESULTS: The mean number of spiral ganglion cells in the contralateral temporal bones in patients with unilateral M{\'e}ni{\`e}re's disease was 17,376.0 and was significantly lower than that in normal controls. The mean loss of inner and outer hair cells in the contralateral temporal bones in patients with unilateral M{\'e}ni{\`e}re's disease was significantly greater than that in normal controls in all turns. The stria vascularis was severely atrophic and degenerated in patients with M{\'e}ni{\`e}re's disease. The mean area of stria vascularis in contralateral temporal bones in patients with unilateral M{\'e}ni{\`e}re's disease was significantly smaller than normal controls. There was no significant difference in the density of fibrocytes in the spiral ligament between the diseased side and the contralateral side in patients with unilateral M{\'e}ni{\`e}re's disease and between normal control and contralateral side. CONCLUSION: The contralateral inner ear in patients with unilateral M{\'e}ni{\`e}re's disease has significantly more damage compared with inner ears of normal controls.",
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AU - Nishizaki, Kazunori

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