Histological findings in non-tumoral liver and tumor after chemoembolization with drug-eluting beads

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the histological findings in both tumor and surrounding non-tumoral liver parenchyma after trans-arterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC) in patients who subsequently underwent hepatectomy. Material and methods: This study included six patients with an HCC (size 15–61 mm). DEB-TACE was performed using polyvinyl alcohol-based hydrogel microspheres loaded with epirubicin. Radiological tumor response was evaluated after DEB-TACE and before hepatectomy, according to the Modified Response Evaluation Criteria in Solid Tumors. Surgical specimens were histologically evaluated with hematoxylin and eosin, and elastic Van Gieson’s staining. Results: Segmental, sub-segmental, or partial hepatectomy were performed 14–58 days after DEB-TACE. There was no remarkable destructive change and minimal to absent inflammatory cell infiltration in the surrounding non-tumoral liver parenchyma. There was no evidence of biliary tract or arterial wall impairment. Complete and partial histological tumor necrosis were found in three cases, respectively, in agreement with the complete and partial responses seen during the radiological evaluation. Conclusion: Histological examination of resected liver specimens after DEB-TACE showed substantial tumor necrosis without any severe inflammatory or destructive changes in the non-tumoral liver parenchyma.

Original languageEnglish
JournalMinimally Invasive Therapy and Allied Technologies
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Hepatectomy
Liver
Pharmaceutical Preparations
Hepatocellular Carcinoma
Neoplasms
Necrosis
Epirubicin
Biliary Tract
Hematoxylin
Eosine Yellowish-(YS)
Microspheres
Staining and Labeling

Keywords

  • drug-eluting beads
  • hepatocellular carcinoma
  • histology
  • Liver
  • trans-arterial chemoembolization

ASJC Scopus subject areas

  • Surgery

Cite this

@article{cc99a3b6fd2148f2a030b4e6c586225a,
title = "Histological findings in non-tumoral liver and tumor after chemoembolization with drug-eluting beads",
abstract = "Purpose: To evaluate the histological findings in both tumor and surrounding non-tumoral liver parenchyma after trans-arterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC) in patients who subsequently underwent hepatectomy. Material and methods: This study included six patients with an HCC (size 15–61 mm). DEB-TACE was performed using polyvinyl alcohol-based hydrogel microspheres loaded with epirubicin. Radiological tumor response was evaluated after DEB-TACE and before hepatectomy, according to the Modified Response Evaluation Criteria in Solid Tumors. Surgical specimens were histologically evaluated with hematoxylin and eosin, and elastic Van Gieson’s staining. Results: Segmental, sub-segmental, or partial hepatectomy were performed 14–58 days after DEB-TACE. There was no remarkable destructive change and minimal to absent inflammatory cell infiltration in the surrounding non-tumoral liver parenchyma. There was no evidence of biliary tract or arterial wall impairment. Complete and partial histological tumor necrosis were found in three cases, respectively, in agreement with the complete and partial responses seen during the radiological evaluation. Conclusion: Histological examination of resected liver specimens after DEB-TACE showed substantial tumor necrosis without any severe inflammatory or destructive changes in the non-tumoral liver parenchyma.",
keywords = "drug-eluting beads, hepatocellular carcinoma, histology, Liver, trans-arterial chemoembolization",
author = "Yusuke Matsui and Hiroyasu Fujiwara and Takao Hiraki and Toshihiro Iguchi and Toshiyuki Komaki and Takehiro Tanaka and Takahito Yagi and Hideo Gobara and Susumu Kanazawa",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/13645706.2019.1626250",
language = "English",
journal = "Minimally Invasive Therapy and Allied Technologies",
issn = "1364-5706",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Histological findings in non-tumoral liver and tumor after chemoembolization with drug-eluting beads

AU - Matsui, Yusuke

AU - Fujiwara, Hiroyasu

AU - Hiraki, Takao

AU - Iguchi, Toshihiro

AU - Komaki, Toshiyuki

AU - Tanaka, Takehiro

AU - Yagi, Takahito

AU - Gobara, Hideo

AU - Kanazawa, Susumu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To evaluate the histological findings in both tumor and surrounding non-tumoral liver parenchyma after trans-arterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC) in patients who subsequently underwent hepatectomy. Material and methods: This study included six patients with an HCC (size 15–61 mm). DEB-TACE was performed using polyvinyl alcohol-based hydrogel microspheres loaded with epirubicin. Radiological tumor response was evaluated after DEB-TACE and before hepatectomy, according to the Modified Response Evaluation Criteria in Solid Tumors. Surgical specimens were histologically evaluated with hematoxylin and eosin, and elastic Van Gieson’s staining. Results: Segmental, sub-segmental, or partial hepatectomy were performed 14–58 days after DEB-TACE. There was no remarkable destructive change and minimal to absent inflammatory cell infiltration in the surrounding non-tumoral liver parenchyma. There was no evidence of biliary tract or arterial wall impairment. Complete and partial histological tumor necrosis were found in three cases, respectively, in agreement with the complete and partial responses seen during the radiological evaluation. Conclusion: Histological examination of resected liver specimens after DEB-TACE showed substantial tumor necrosis without any severe inflammatory or destructive changes in the non-tumoral liver parenchyma.

AB - Purpose: To evaluate the histological findings in both tumor and surrounding non-tumoral liver parenchyma after trans-arterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC) in patients who subsequently underwent hepatectomy. Material and methods: This study included six patients with an HCC (size 15–61 mm). DEB-TACE was performed using polyvinyl alcohol-based hydrogel microspheres loaded with epirubicin. Radiological tumor response was evaluated after DEB-TACE and before hepatectomy, according to the Modified Response Evaluation Criteria in Solid Tumors. Surgical specimens were histologically evaluated with hematoxylin and eosin, and elastic Van Gieson’s staining. Results: Segmental, sub-segmental, or partial hepatectomy were performed 14–58 days after DEB-TACE. There was no remarkable destructive change and minimal to absent inflammatory cell infiltration in the surrounding non-tumoral liver parenchyma. There was no evidence of biliary tract or arterial wall impairment. Complete and partial histological tumor necrosis were found in three cases, respectively, in agreement with the complete and partial responses seen during the radiological evaluation. Conclusion: Histological examination of resected liver specimens after DEB-TACE showed substantial tumor necrosis without any severe inflammatory or destructive changes in the non-tumoral liver parenchyma.

KW - drug-eluting beads

KW - hepatocellular carcinoma

KW - histology

KW - Liver

KW - trans-arterial chemoembolization

UR - http://www.scopus.com/inward/record.url?scp=85067548037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067548037&partnerID=8YFLogxK

U2 - 10.1080/13645706.2019.1626250

DO - 10.1080/13645706.2019.1626250

M3 - Article

AN - SCOPUS:85067548037

JO - Minimally Invasive Therapy and Allied Technologies

JF - Minimally Invasive Therapy and Allied Technologies

SN - 1364-5706

ER -