Histological and Nuclear Medical Comparison of Inflammation after Hemostasis with Non-Thermal Plasma and Thermal Coagulation

Masashi Ueda, Daiki Yamagami, Keiko Watanabe, Asami Mori, Hiroyuki Kimura, Kohei Sano, Hideo Saji, Kenji Ishikawa, Masaru Hori, Hajime Sakakita, Yuzuru Ikehara, Shuichi Enomoto

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Abstract

The objective of this study is to examine the invasiveness of hemostasis by non-thermal plasma (NTP) compared with hemostasis by thermal coagulation (TC). The inflammation recovery process after hemostasis by TC and NTP was compared by using histological methods and nuclear medical molecular imaging. The necrotic areas in the NTP group disappeared after 5 days, whereas they remained 15 days after hemostasis in the TC group. The accumulation of 2-deoxy-2-[18F]fluoro-d-glucopyranose (18F-FDG), which reflects the existence of inflammatory cells, was higher in the TC group than in the NTP group on day 15. Thus, this study indicates that hemostasis by NTP is less inflammatory than TC. This report is the first to evaluate inflammation that occurred after hemostasis with medical devices noninvasively.

Original languageEnglish
Pages (from-to)1338-1342
Number of pages5
JournalPlasma Processes and Polymers
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

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Keywords

  • hemostasis
  • imaging
  • inflammation
  • non-thermal plasma
  • positron emission tomography

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Polymers and Plastics

Cite this

Ueda, M., Yamagami, D., Watanabe, K., Mori, A., Kimura, H., Sano, K., Saji, H., Ishikawa, K., Hori, M., Sakakita, H., Ikehara, Y., & Enomoto, S. (2015). Histological and Nuclear Medical Comparison of Inflammation after Hemostasis with Non-Thermal Plasma and Thermal Coagulation. Plasma Processes and Polymers, 12(12), 1338-1342. https://doi.org/10.1002/ppap.201500099