Histological and immunohistochemical features of gingival enlargement in a patient with AML

Norihiro Sonoi, Yoshihiko Soga, Hiroshi Maeda, Koichi Ichimura, Tadashi Yoshino, Kazutoshi Aoyama, Nobuharu Fujii, Yoshinobu Maeda, Mitsune Tanimoto, Richard Logan, Judith Raber-Durlacher, Shogo Takashiba

Research output: Contribution to journalArticle

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Abstract

Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed both before and after chemotherapy. The patient was a 39-year-old Japanese woman with AML-M4 showing gingival enlargement. Histological and immunohistochemical features of gingiva and bacterial counts in the periodontal pockets were examined before and after chemotherapy. The results were as follows: (1) infiltration of myelomonocytic blasts in enlarged gingiva; (2) resolution of gingival enlargement with complete remission of AML by anticancer chemotherapy; and (3) the numbers of bacteria in the periodontal pockets were not high and were not altered before or after chemotherapy. In patients with AML-M4, remarkable mucosal enlargement is not generally observed in the body except in the gingiva. We hypothesized that antigens derived from periodontal bacteria, even if they are not present in large numbers, could act as chemoattractants for myelomonocytic leukemic cells.

Original languageEnglish
Pages (from-to)254-257
Number of pages4
JournalOdontology
Volume100
Issue number2
DOIs
Publication statusPublished - Jul 2012

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Gingiva
Periodontal Pocket
Drug Therapy
Leukemia, Myelomonocytic, Acute
Bacteria
Bacterial Load
Chemotactic Factors
Leukemia
Biopsy
Antigens

Keywords

  • Acute myelomonocytic leukemia
  • Gingival enlargement
  • Histology
  • Immunohistochemistry
  • Pathogenesis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Histological and immunohistochemical features of gingival enlargement in a patient with AML. / Sonoi, Norihiro; Soga, Yoshihiko; Maeda, Hiroshi; Ichimura, Koichi; Yoshino, Tadashi; Aoyama, Kazutoshi; Fujii, Nobuharu; Maeda, Yoshinobu; Tanimoto, Mitsune; Logan, Richard; Raber-Durlacher, Judith; Takashiba, Shogo.

In: Odontology, Vol. 100, No. 2, 07.2012, p. 254-257.

Research output: Contribution to journalArticle

Sonoi, Norihiro ; Soga, Yoshihiko ; Maeda, Hiroshi ; Ichimura, Koichi ; Yoshino, Tadashi ; Aoyama, Kazutoshi ; Fujii, Nobuharu ; Maeda, Yoshinobu ; Tanimoto, Mitsune ; Logan, Richard ; Raber-Durlacher, Judith ; Takashiba, Shogo. / Histological and immunohistochemical features of gingival enlargement in a patient with AML. In: Odontology. 2012 ; Vol. 100, No. 2. pp. 254-257.
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