Histologic transformation of follicular lymphoma after allogeneic bone marrow transplantation

K. Kojima, T. Mannami, T. Yoshino, H. Kawasaki, K. Sasaki, T. Maeda, K. Furuya, M. Harada, M. Hara

Research output: Contribution to journalArticle

Abstract

A 38-year-old man with refractory follicular lymphoma underwent allogeneic BMT from an HLA-identical sibling donor. He had generalized lymphadenopathy, hepatosplenomegaly and lymphoma infiltration of the marrow, all of which disappeared within 3 months following transplantation. Six months post-transplant, progressive hepatomegaly developed in the absence of splenomegaly and lymphadenopathy, and he died from hepatic failure. Autopsy disclosed diffuse large B cell lymphoma of the liver, into which the follicular lymphoma had transformed. Future issues to be investigated should include the optimal timing of allogeneic BMT for low-grade lymphomas.

Original languageEnglish
Pages (from-to)581-583
Number of pages3
JournalBone Marrow Transplantation
Volume26
Issue number5
DOIs
Publication statusPublished - 2000

Keywords

  • Allogeneic bone marrow transplantation
  • Diffuse large B cell lymphoma
  • Follicular lymphoma
  • Histologic transformation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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  • Cite this

    Kojima, K., Mannami, T., Yoshino, T., Kawasaki, H., Sasaki, K., Maeda, T., Furuya, K., Harada, M., & Hara, M. (2000). Histologic transformation of follicular lymphoma after allogeneic bone marrow transplantation. Bone Marrow Transplantation, 26(5), 581-583. https://doi.org/10.1038/sj.bmt.1702547