Histamine Turnover in the Rat Hypothalamic Nuclei Estimated from α-Fluoromethylhistidine-lnduced Histamine Decrease

Yoshinori Itoh, Ryozo Oishi, Masahiro Nishibori, Kiyomi Saeki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The turnover rates, rate constants and half-life values of neuronal histamine (HA) in 10 nuclei of the rat hypothalamus were estimated from the depletion of HA induced by α-fluoromethylhistidine (α-FMH: 100 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, on the presumption that α-FMH depletable HA pools represent neuronal ones. Marked variation in the HA turnover rates were observed among the hypothalamic nuclei, ranging from 5.7 to 19.5 pmo!e/mg protein/hr.

Original languageEnglish
Pages (from-to)581-584
Number of pages4
Journalthe japanese journal of pharmacology
Volume51
Issue number4
DOIs
Publication statusPublished - Mar 28 1988

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Histamine Turnover in the Rat Hypothalamic Nuclei Estimated from α-Fluoromethylhistidine-lnduced Histamine Decrease'. Together they form a unique fingerprint.

  • Cite this