Histamine turnover in the rat hypothalamic nuclei estimated from α-fluoromethylhistidine-induced histamine decrease

Y. Itoh, R. Oishi, Masahiro Nishibori, K. Saeki

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Abstract

The turnover rates, rate constants and half-life values of neuronal histamine (HA) in 10 nuclei of the rat hypothalamus were estimated from the depletion of HA induced by α-fluoromethylhistidine (α-FMH: 100 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, on the presumption that α-FMH depletable HA pools represent neuronal ones. Marked variation in the HA turnover rates were observed among the hypothalamic nuclei, ranging from 5.7 to 19.5 pmole/mg protein/hr.

Original languageEnglish
Pages (from-to)581-584
Number of pages4
JournalJapanese Journal of Pharmacology
Volume51
Issue number4
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Pharmacology

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