Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells

Hideo Kohka Takahashi, Atsushi Yoshida, Hiromi Iwagaki, Tadashi Yoshino, Hideyuki Itoh, Toshihiko Morichika, Minori Yokoyama, Tadaatsu Akagi, Noriaki Tanaka, Shuji Mori, Masahiro Nishibori

Research output: Contribution to journalArticle

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Abstract

In the previous study, we demonstrated that interleukin (IL)-18 up-regulated intercellular adhesion molecule-1 (ICAM-1) expression on monocytes in human peripheral blood mononuclear cells (PBMC) and that heterotypic interaction between monocytes/T or NK cells through ICAM-1/LFA-1 intensified the production of IL-12, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α) in PBMC. In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-γ, and TNF-α induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. The modulatory effects of histamine on ICAM-1 expression and cytokine production were all concentration dependently antagonized by famotidine but not by d-chlorpheniramine and thioperamide, and were mimicked by selective H2-receptor agonists but not by H1- and H3-receptor agonists, indicating the involvement of H2-receptors in histamine action. The inhibition of IL-18-induced IFN-γ by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine thus operates the negative feedback mechanism against IL-18-activated cytokine cascade through the strong inhibitory effect on ICAM-1 expression and IL-12 production in monocytes, contributing to the formation of diverse pattern of cytokine activation from Th1 to Th2, depending on the monocyte/macrophage activation and cytokine environment.

Original languageEnglish
Pages (from-to)227-235
Number of pages9
JournalJournal of Pharmacology and Experimental Therapeutics
Volume300
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Interleukin-18
Intercellular Adhesion Molecule-1
Histamine
Blood Cells
Down-Regulation
Cytokines
Monocytes
Interleukin-12
Histamine Agonists
Interferons
Histamine H2 Receptors
thioperamide
Tumor Necrosis Factor-alpha
Histamine H3 Receptors
Chlorpheniramine
Famotidine
Histamine H1 Receptors
Lymphocyte Function-Associated Antigen-1
Macrophage Activation
Cell Communication

ASJC Scopus subject areas

  • Pharmacology

Cite this

Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells. / Takahashi, Hideo Kohka; Yoshida, Atsushi; Iwagaki, Hiromi; Yoshino, Tadashi; Itoh, Hideyuki; Morichika, Toshihiko; Yokoyama, Minori; Akagi, Tadaatsu; Tanaka, Noriaki; Mori, Shuji; Nishibori, Masahiro.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 300, No. 1, 2002, p. 227-235.

Research output: Contribution to journalArticle

Takahashi, Hideo Kohka ; Yoshida, Atsushi ; Iwagaki, Hiromi ; Yoshino, Tadashi ; Itoh, Hideyuki ; Morichika, Toshihiko ; Yokoyama, Minori ; Akagi, Tadaatsu ; Tanaka, Noriaki ; Mori, Shuji ; Nishibori, Masahiro. / Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells. In: Journal of Pharmacology and Experimental Therapeutics. 2002 ; Vol. 300, No. 1. pp. 227-235.
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AU - Takahashi, Hideo Kohka

AU - Yoshida, Atsushi

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AU - Yoshino, Tadashi

AU - Itoh, Hideyuki

AU - Morichika, Toshihiko

AU - Yokoyama, Minori

AU - Akagi, Tadaatsu

AU - Tanaka, Noriaki

AU - Mori, Shuji

AU - Nishibori, Masahiro

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