Histamine H1 receptors are involved in mouse nasal allergic responses: A demonstration with H1 receptor-deficient mice

Ryoji Kayasuga, Yukio Sugimoto, Takeshi Watanabe, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The role of histamine H1 receptors in nasal allergic symptoms (sneezing and nasal rubbing) were studied using histamine H1 receptor-deficient mice. Intranasal instillation of histamine solution resulted in significant increases in sneezing and nasal rubbing in wild-type mice, whereas no increases were observed in histamine H1 receptor-deficient mice. The histamine H1 receptor agonist 2-pyridylethylamine induced sneezing and nasal rubbing in a dose-dependent manner in wild-type mice, but no such increase was found in histamine H1 receptor-deficient mice. On the other hand, the histamine H2 receptor agonist dimaprit did not increase sneezing and nasal rubbing in wild-type mice. Histamine H1 receptor antagonists such as chlorpheniramine and epinastine significantly inhibited nasal allergic symptoms caused by histamine, but the histamine H2 receptor antagonists cimetidine and famotidine showed no effect. No additional effects were observed by combined use of chlorpheniramine and cimetidine or famotidine compared with cimetidine or famotidine alone. These results suggested that histamine H1 receptors play an important role in nasal allergy symptoms induced by histamine.

Original languageEnglish
Pages (from-to)745-750
Number of pages6
JournalInternational Immunopharmacology
Volume2
Issue number6
DOIs
Publication statusPublished - Jun 18 2002

Keywords

  • Histamine
  • Histamine H receptor
  • Nasal allergic symptoms
  • Nasal rubbing
  • Sneezing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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