Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice

Maria Alejandra Hossen, Yoko Fujii, Yukio Sugimoto, Ryoji Kayasuga, Chiaki Kamei

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The participation of histamine H3 receptors in the regulation of skin vascular permeability changes in mast cell-deficient mice was studied. Although intradermal injection of histamine H3 antagonists, iodophenpropit and clobenpropit, at a dose of 100 nmol/site caused significant increases in skin vascular permeability in both mast cell-deficient (WBB6F1 W/Wv) and wild-type (WBB6F1 +/+) mice, this response was significantly lower in mast cell-deficient mice than in the wild-type controls. Histamine also caused dose-related increases in skin vascular permeability in both wild-type and mast cell-deficient mice. Significant effects were observed at doses of 10 and 100 nmol/site, and no significant difference in skin vascular permeability was observed between mast cell-deficient and wild-type mice. However, histamine contents of dorsal skin in mast cell-deficient mice were significantly lower than in wild-type mice. In addition, the H1 antagonists diphenhydramine and chlorpheniramine and the NK1 antagonists, L-732,138 and L-733,060, were able to antagonize H3 antagonist-induced skin vascular permeability. These results indicated that blockade of H3 receptors by H3 antagonists induce skin vascular permeability through mast cell-dependent mechanisms. In addition, histamine and, to a lesser extent substance P are involved in the reaction.

Original languageEnglish
Pages (from-to)1563-1568
Number of pages6
JournalInternational Immunopharmacology
Volume3
Issue number12
DOIs
Publication statusPublished - Nov 2003

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Histamine H3 Receptors
Capillary Permeability
Mast Cells
Skin
Histamine
3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine
Histamine H3 Antagonists
Chlorpheniramine
Diphenhydramine
Intradermal Injections
Substance P

Keywords

  • H agonists
  • H antagonists
  • Histamine
  • Vascular permeability

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice. / Hossen, Maria Alejandra; Fujii, Yoko; Sugimoto, Yukio; Kayasuga, Ryoji; Kamei, Chiaki.

In: International Immunopharmacology, Vol. 3, No. 12, 11.2003, p. 1563-1568.

Research output: Contribution to journalArticle

Hossen, Maria Alejandra ; Fujii, Yoko ; Sugimoto, Yukio ; Kayasuga, Ryoji ; Kamei, Chiaki. / Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice. In: International Immunopharmacology. 2003 ; Vol. 3, No. 12. pp. 1563-1568.
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