Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Koreaki Sugimoto, Koji Abe, Tsong Hai Lee, Eiko Sakurai, Kazuhiko Yanai, Kyuya Kogure, Yasuto Itoyama, Takehiko Watanabe

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalBrain Research
Volume666
Issue number2
DOIs
Publication statusPublished - Dec 15 1994
Externally publishedYes

Keywords

  • (S)α-Fluoromethylhistidine
  • CA2
  • Gerbil
  • Hippocampus
  • Histamine
  • Ischemia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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