Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Koreaki Sugimoto, Koji Abe, Tsong Hai Lee, Eiko Sakurai, Kazuhiko Yanai, Kyuya Kogure, Yasuto Itoyama, Takehiko Watanabe

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalBrain Research
Volume666
Issue number2
DOIs
Publication statusPublished - Dec 15 1994
Externally publishedYes

Fingerprint

Gerbillinae
Histamine
Ischemia
Neurons
Brain
Subcutaneous Injections
Prosencephalon
Histidine
Hippocampus
Therapeutics

Keywords

  • (S)α-Fluoromethylhistidine
  • CA2
  • Gerbil
  • Hippocampus
  • Histamine
  • Ischemia

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons. / Sugimoto, Koreaki; Abe, Koji; Lee, Tsong Hai; Sakurai, Eiko; Yanai, Kazuhiko; Kogure, Kyuya; Itoyama, Yasuto; Watanabe, Takehiko.

In: Brain Research, Vol. 666, No. 2, 15.12.1994, p. 279-283.

Research output: Contribution to journalArticle

Sugimoto, Koreaki ; Abe, Koji ; Lee, Tsong Hai ; Sakurai, Eiko ; Yanai, Kazuhiko ; Kogure, Kyuya ; Itoyama, Yasuto ; Watanabe, Takehiko. / Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons. In: Brain Research. 1994 ; Vol. 666, No. 2. pp. 279-283.
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