Abstract
Two Nobel couplings: The synthesis of tri- and tetraalkylated olefins has been achieved (see scheme). These multialkylated olefins were prepared by the zirconocene-mediated carbometalation of 1-alkynylboronates and subsequent sequential C-C bond formation with Negishi and Suzuki-Miyaura cross-coupling reactions using β-hydrogen-containing alkylzinc reagents and alkyl electrophiles as coupling partners.
Original language | English |
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Pages (from-to) | 8660-8664 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 37 |
DOIs | |
Publication status | Published - Sep 5 2011 |
Keywords
- Negishi coupling
- Suzuki-Miyaura coupling
- cross-coupling
- palladium
- zirconacycles
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)