Abstract
Two Nobel couplings: The synthesis of tri- and tetraalkylated olefins has been achieved (see scheme). These multialkylated olefins were prepared by the zirconocene-mediated carbometalation of 1-alkynylboronates and subsequent sequential C-C bond formation with Negishi and Suzuki-Miyaura cross-coupling reactions using β-hydrogen-containing alkylzinc reagents and alkyl electrophiles as coupling partners.
| Original language | English |
|---|---|
| Pages (from-to) | 8660-8664 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 37 |
| DOIs | |
| Publication status | Published - Sep 5 2011 |
Keywords
- Negishi coupling
- Suzuki-Miyaura coupling
- cross-coupling
- palladium
- zirconacycles
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Nishihara, Y., Okada, Y., Jiao, J., Suetsugu, M., Lan, M. T., Kinoshita, M., Iwasaki, M., & Takagi, K. (2011). Highly regio- and stereoselective synthesis of multialkylated olefins through carbozirconation of alkynylboronates and sequential Negishi and Suzuki-Miyaura coupling reactions. Angewandte Chemie - International Edition, 50(37), 8660-8664. https://doi.org/10.1002/anie.201103601