Highly reactive bifunctional chemical catalysts for the hydration of nitriles

Toshiyuki Oshiki, Isao Hyodo, Akinori Ishizuka

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

New bifunctional chemical catalysts for the hydration of nitriles are described. cis-Ru(acac)2(PPh2py)2 exhibited high activity, with a turnover frequency of up to 20,900 (mol of amide)/((mol of catalyst)h). Newly synthesized iridium complexes bearing a PPh2py ligand have a 16 e" square planar structure. The catalytic hydration of nitriles proceeded at 80 °C within few hours to give corresponding amides in almost quantitative yield. Moreover, the iridium complexes acted as a catalyst for the hydration under solvent-free conditions. In addition, new catalysts based on palladium nanoparticles for the hydration are described. Copper compounds containing oxygen atom acted as effective co-catalysts in the catalytic system.

Original languageEnglish
Pages (from-to)41-51
Number of pages11
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 1 2010

Keywords

  • Amide
  • Homogeneous catalyst catalysis
  • Hydration
  • Iridium
  • Nanoparticle
  • Ruthenium
  • Water

ASJC Scopus subject areas

  • Organic Chemistry

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