Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent

Tadashi Ema, Masafumi Kageyama, Toshinobu Korenaga, Takashi Sakai

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.

Original languageEnglish
Pages (from-to)3943-3947
Number of pages5
JournalTetrahedron Asymmetry
Volume14
Issue number24
DOIs
Publication statusPublished - Dec 12 2003

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Lipases
Lipase
Organic solvents
enzymes
ceramics
Temperature
kinetics
products
Burkholderia cepacia
Enzyme kinetics
2-Propanol
Enantioselectivity
Ceramics
Propanol
Enzymes
Kinetics

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent. / Ema, Tadashi; Kageyama, Masafumi; Korenaga, Toshinobu; Sakai, Takashi.

In: Tetrahedron Asymmetry, Vol. 14, No. 24, 12.12.2003, p. 3943-3947.

Research output: Contribution to journalArticle

Ema, Tadashi ; Kageyama, Masafumi ; Korenaga, Toshinobu ; Sakai, Takashi. / Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent. In: Tetrahedron Asymmetry. 2003 ; Vol. 14, No. 24. pp. 3943-3947.
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