Abstract
Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.
| Original language | English |
|---|---|
| Pages (from-to) | 3943-3947 |
| Number of pages | 5 |
| Journal | Tetrahedron Asymmetry |
| Volume | 14 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - Dec 12 2003 |
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
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Ema, T., Kageyama, M., Korenaga, T., & Sakai, T. (2003). Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent. Tetrahedron Asymmetry, 14(24), 3943-3947. https://doi.org/10.1016/j.tetasy.2003.09.040