Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent

Tadashi Ema; Masafumi Kageyama; Toshinobu Korenaga; Takashi Sakai

doi:10.1016/j.tetasy.2003.09.040

Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent

Tadashi Ema, Masafumi Kageyama, Toshinobu Korenaga, Takashi Sakai

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.

Original language	English
Pages (from-to)	3943-3947
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	14
Issue number	24
DOIs	https://doi.org/10.1016/j.tetasy.2003.09.040
Publication status	Published - Dec 12 2003

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent",

abstract = "Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.",

author = "Tadashi Ema and Masafumi Kageyama and Toshinobu Korenaga and Takashi Sakai",

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language = "English",

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T1 - Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent

AU - Ema, Tadashi

AU - Kageyama, Masafumi

AU - Korenaga, Toshinobu

AU - Sakai, Takashi

PY - 2003/12/12

Y1 - 2003/12/12

N2 - Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.

AB - Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.

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EP - 3947

JO - Tetrahedron Asymmetry

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