Abstract
Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.
| Original language | English |
|---|---|
| Pages (from-to) | 3943-3947 |
| Number of pages | 5 |
| Journal | Tetrahedron Asymmetry |
| Volume | 14 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - Dec 12 2003 |
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ASJC Scopus subject areas
- Inorganic Chemistry
- Organic Chemistry
- Materials Chemistry
- Drug Discovery
Cite this
Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent. / Ema, Tadashi; Kageyama, Masafumi; Korenaga, Toshinobu; Sakai, Takashi.
In: Tetrahedron Asymmetry, Vol. 14, No. 24, 12.12.2003, p. 3943-3947.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent
AU - Ema, Tadashi
AU - Kageyama, Masafumi
AU - Korenaga, Toshinobu
AU - Sakai, Takashi
PY - 2003/12/12
Y1 - 2003/12/12
N2 - Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.
AB - Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.
UR - http://www.scopus.com/inward/record.url?scp=0345602146&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345602146&partnerID=8YFLogxK
U2 - 10.1016/j.tetasy.2003.09.040
DO - 10.1016/j.tetasy.2003.09.040
M3 - Article
AN - SCOPUS:0345602146
VL - 14
SP - 3943
EP - 3947
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
SN - 0957-4166
IS - 24
ER -