TY - JOUR
T1 - Highly enantioselective lipase-catalyzed reactions at high temperatures up to 120°C in organic solvent
AU - Ema, Tadashi
AU - Kageyama, Masafumi
AU - Korenaga, Toshinobu
AU - Sakai, Takashi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We also thank Venture Business Laboratory of Okayama University for financial support. We are grateful to the SC-NMR Laboratory of Okayama University for the measurement of NMR spectra.
PY - 2003/12/12
Y1 - 2003/12/12
N2 - Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.
AB - Lipase-catalyzed kinetic resolutions of 1,1-diphenyl-2-propanol were performed at high temperatures up to 120°C. Burkholderia cepacia lipase immobilized on porous ceramic particles, lipase PS-C II (Amano Enzyme Inc.), gave an enantiopure product at 40-120°C, with the highest conversion (39%) at 80-90°C. The mechanism of high enantioselectivity retained even at 120°C is also described briefly.
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U2 - 10.1016/j.tetasy.2003.09.040
DO - 10.1016/j.tetasy.2003.09.040
M3 - Article
AN - SCOPUS:0345602146
VL - 14
SP - 3943
EP - 3947
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
SN - 0957-4166
IS - 24
ER -