Highly Enantioselective and Efficient Synthesis of Methyl (R)-o-Chloromandelate, Key Intermediate for Clopidogrel Synthesis, with Recombinant Escherichia coli.

David Pollard, Matthew Truppo, Jeffrey Moore, Birgit Kosjek, David Tellers, Jeffrey Moore, Ioulia Smonou, Dimitris Kalaitzakis, Musa M. Musa, Karla I. Ziegelmann-Fjeld, Claire Vieille, J. Gregory Zeikus, Robert S. Phillipsa, Matthew Truppo, Krista Morley, Paul Devine, Tadashi Ema, Nobuyasu Okita, Sayaka Ide, Takashi Sakai

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publicationPractical Methods for Biocatalysis and Biotransformations
PublisherJohn Wiley & Sons, Ltd
Pages291-294
Number of pages4
ISBN (Print)9780470519271
DOIs
Publication statusPublished - Dec 15 2009

Keywords

  • Nicotinamide adenine dinucleotidephosphate(NADPH)-dependent ketoreductases(KREDs)
  • Synthesis of chiral sec-alcohols by ketone reduction

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Pollard, D., Truppo, M., Moore, J., Kosjek, B., Tellers, D., Moore, J., Smonou, I., Kalaitzakis, D., Musa, M. M., Ziegelmann-Fjeld, K. I., Vieille, C., Zeikus, J. G., Phillipsa, R. S., Truppo, M., Morley, K., Devine, P., Ema, T., Okita, N., Ide, S., & Sakai, T. (2009). Highly Enantioselective and Efficient Synthesis of Methyl (R)-o-Chloromandelate, Key Intermediate for Clopidogrel Synthesis, with Recombinant Escherichia coli. In Practical Methods for Biocatalysis and Biotransformations (pp. 291-294). John Wiley & Sons, Ltd. https://doi.org/10.1002/9780470748589.ch8