Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: Toward practical and green access to clopidogrel

Tadashi Ema, Nobuyasu Okita, Sayaka Ide, Takashi Sakai

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Methyl (R)-o-chloromandelate ((R)-1), which is an intermediate for a platelet aggregation inhibitor named clopidogrel, was obtained in >99% ee by the asymmetric reduction of methyl o-chlorobenzoylformate (2) (up to 1.0 M) with recombinant E. coli overproducing a versatile carbonyl reductase.

Original languageEnglish
Pages (from-to)1175-1176
Number of pages2
JournalOrganic and Biomolecular Chemistry
Volume5
Issue number8
DOIs
Publication statusPublished - Apr 12 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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