Highly efficient, catalytic Meerwein-Ponndorf-Verley reduction with a novel bidentate aluminum catalyst

Takashi Ooi, Tomoya Miura, Keiji Maruoka

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)

Abstract

Double electrophilic activation of carbonyl groups allows a modern variant of the Meerwein-Ponndorf-Verley reduction to be carried out under mild conditions with bidentate catalyst 1 (see reaction). Various carbonyl substrates can be reduced efficiently at room temperature in CH2Cl2 with 2-propanol or sec-phenthyl alcohol in the presence of a catalytic amount of 1. This system is also applicable to the Oppenauer oxidation of secondary alcohols to the corresponding ketones.

Original languageEnglish
Pages (from-to)2347-2349
Number of pages3
JournalAngewandte Chemie - International Edition
Volume37
Issue number17
DOIs
Publication statusPublished - Sep 18 1998
Externally publishedYes

Keywords

  • Aluminum
  • Asymmetric synthesis
  • Homogeneous catalysis
  • Oxidations
  • Reductions

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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