Highly effective dephosphorylation of F-1-alkenyl phosphates with copper halide-lithium aluminium hydride reagent: A new access to 1-hydryl-F-alkyl ketones from F-alkyl ketones

Takashi Ishihara, Manabu Kuroboshi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

1-Substituted F-1-alkenyl phosphate, readily available from F-alkyl ketones and diethyl phosphite, undergo the dephosphorylation by the action of copper(I) or copper(II) bromide and lithium aluminium hydride at -78 °C followed by hydrolysis to give the corresponding 1-hydryl-F-alkyl ketones in good to excellent yields.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalJournal of Fluorine Chemistry
Volume37
Issue number1
DOIs
Publication statusPublished - Oct 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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