Abstract
1-Substituted F-1-alkenyl phosphate, readily available from F-alkyl ketones and diethyl phosphite, undergo the dephosphorylation by the action of copper(I) or copper(II) bromide and lithium aluminium hydride at -78 °C followed by hydrolysis to give the corresponding 1-hydryl-F-alkyl ketones in good to excellent yields.
| Original language | English |
|---|---|
| Pages (from-to) | 113-118 |
| Number of pages | 6 |
| Journal | Journal of Fluorine Chemistry |
| Volume | 37 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 1987 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Environmental Chemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
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Cite this
Ishihara, T., & Kuroboshi, M. (1987). Highly effective dephosphorylation of F-1-alkenyl phosphates with copper halide-lithium aluminium hydride reagent: A new access to 1-hydryl-F-alkyl ketones from F-alkyl ketones. Journal of Fluorine Chemistry, 37(1), 113-118. https://doi.org/10.1016/S0022-1139(00)83092-4