Higher incidence and serum levels of minor cardiac biomarker elevation in sirolimus-eluting stent (Cypher) than bare metal stent implantations

Tetsushi Seitou, Masaaki Murakami, Issei Komatsubara, Hiroshi Kawamura, Keizo Yamamoto, Kazuyoshi Hina, Satoshi Hirohata, Ryouko Shinohata, Yoshifumi Ninomiya, Shozo Kusachi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVES: Minor cardiac biomarker elevation after percutaneous coronary intervention has long-term prognostic significance. The sirolimus-eluting stent (Cypher) has been reported to require high postinflation pressure for optimal implantation. We examined the incidence of minor cardiac biomarker elevation induced by Cypher implantation. METHODS: We measured the serum concentration of cardiac troponin-I (cTnI) 24 h after stenting and those of creatine kinase isoenzyme MB and creatine kinase before, immediately after, and 6, 12 and 24 h after implantation in patients who underwent Cypher stent (CS group; n=53) or bare metal stent (BMS group; n=57) implantation. RESULTS: No significant difference in clinical background was observed between the two groups. When a cutoff cTnI value of 0.50 ng/ml was used, the CS group showed a significantly higher incidence of cTnI elevation (35.8%, 19/53) than the BMS group (14.0%, 8/57) (P

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalCoronary Artery Disease
Volume19
Issue number2
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Troponin I
Sirolimus
Stents
Biomarkers
Metals
Incidence
Serum
MB Form Creatine Kinase
Percutaneous Coronary Intervention
Creatine Kinase
Isoenzymes
Pressure

Keywords

  • Coronary disease
  • Coronary intervention
  • Creatine kinase
  • Drugs
  • Myocardial injury
  • Stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Higher incidence and serum levels of minor cardiac biomarker elevation in sirolimus-eluting stent (Cypher) than bare metal stent implantations. / Seitou, Tetsushi; Murakami, Masaaki; Komatsubara, Issei; Kawamura, Hiroshi; Yamamoto, Keizo; Hina, Kazuyoshi; Hirohata, Satoshi; Shinohata, Ryouko; Ninomiya, Yoshifumi; Kusachi, Shozo.

In: Coronary Artery Disease, Vol. 19, No. 2, 03.2008, p. 63-69.

Research output: Contribution to journalArticle

Seitou, Tetsushi ; Murakami, Masaaki ; Komatsubara, Issei ; Kawamura, Hiroshi ; Yamamoto, Keizo ; Hina, Kazuyoshi ; Hirohata, Satoshi ; Shinohata, Ryouko ; Ninomiya, Yoshifumi ; Kusachi, Shozo. / Higher incidence and serum levels of minor cardiac biomarker elevation in sirolimus-eluting stent (Cypher) than bare metal stent implantations. In: Coronary Artery Disease. 2008 ; Vol. 19, No. 2. pp. 63-69.
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AU - Kawamura, Hiroshi

AU - Yamamoto, Keizo

AU - Hina, Kazuyoshi

AU - Hirohata, Satoshi

AU - Shinohata, Ryouko

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