High-turnover osteopenia in preterm infants

Determination of urinary pyridinium cross-links of collagen

Hirokazu Tsukahara, Motohiro Takeuchi, Kazuo Fujisawa, Masakazu Miura, Keishi Hata, Kazutaka Yamamoto, Mitsufumi Mayumi

Research output: Contribution to journalArticle

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Abstract

Osteopenia is a frequent condition in preterm infants, but its pathogenesis is uncertain. In the present study, we measured longitudinal changes in the excretion of pyridinium cross-links of collagen (specific markers of bone resorption) and evaluated the relationship between collagen cross-links and other indexes of bone and renal function in preterm infants. In these infants, urinary collagen cross-links were markedly increased on day 7 and day 30 of life and at estimated full-term gestation. The values were several times higher than those of older children and almost comparable to those of healthy full-term infants. Cross-link excretion did not correlate with β2-microglobulin (B2M) or N-acetyl-β-D-glucosaminidase (NAG) activity (markers of renal function), indicating that cross-link excretion is not influenced directly by infantile renal function. High serum osteocalcin and low bone mineral density (BMD) in the lumbar spine were also observed at estimated full-term gestation. There was no significant correlation between collagen cross-link excretion and either serum osteocalcin or spine BMD. We conclude that a state of high bone turnover underlies the development of osteopenia in preterm infants.

Original languageEnglish
Pages (from-to)333-335
Number of pages3
JournalMetabolism: Clinical and Experimental
Volume47
Issue number3
DOIs
Publication statusPublished - 1998
Externally publishedYes

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Metabolic Bone Diseases
Premature Infants
Collagen
Osteocalcin
Kidney
Bone Density
Spine
Hexosaminidases
Pregnancy
Bone Remodeling
Bone Resorption
Serum
Bone and Bones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

High-turnover osteopenia in preterm infants : Determination of urinary pyridinium cross-links of collagen. / Tsukahara, Hirokazu; Takeuchi, Motohiro; Fujisawa, Kazuo; Miura, Masakazu; Hata, Keishi; Yamamoto, Kazutaka; Mayumi, Mitsufumi.

In: Metabolism: Clinical and Experimental, Vol. 47, No. 3, 1998, p. 333-335.

Research output: Contribution to journalArticle

Tsukahara, Hirokazu ; Takeuchi, Motohiro ; Fujisawa, Kazuo ; Miura, Masakazu ; Hata, Keishi ; Yamamoto, Kazutaka ; Mayumi, Mitsufumi. / High-turnover osteopenia in preterm infants : Determination of urinary pyridinium cross-links of collagen. In: Metabolism: Clinical and Experimental. 1998 ; Vol. 47, No. 3. pp. 333-335.
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