High-throughput screening of bioactive compounds via new catalytic reaction in the pooled mixture

Research output: Contribution to journalArticle

Abstract

To increase the chances of finding new candidate molecules with medicinal properties, while expending less resource and effort, the present study used pooled substrates as starting materials. A bisindole compound that showed inhibitory activity was then isolated from the mixture, and the activity was improved by optimizing the substituents on the indole skeleton.

Original languageEnglish
JournalBioorganic and Medicinal Chemistry Letters
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Skeleton
Screening
Throughput
Molecules
Substrates
indole

Keywords

  • Bisindole
  • Brefeldin A
  • Golgi
  • High-throughput screening
  • Secretion

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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abstract = "To increase the chances of finding new candidate molecules with medicinal properties, while expending less resource and effort, the present study used pooled substrates as starting materials. A bisindole compound that showed inhibitory activity was then isolated from the mixture, and the activity was improved by optimizing the substituents on the indole skeleton.",
keywords = "Bisindole, Brefeldin A, Golgi, High-throughput screening, Secretion",
author = "Ayano Satoh and Yuta Nishina",
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